{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,23]],"date-time":"2025-11-23T03:08:46Z","timestamp":1763867326005,"version":"3.40.5"},"reference-count":37,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2022,3,29]],"date-time":"2022-03-29T00:00:00Z","timestamp":1648512000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2022,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Salivary duct carcinoma (SDC) is a high\u2010grade salivary malignancy that frequently occurs as the carcinomatous component of carcinoma ex pleomorphic adenoma. We herein examined the clinical factors affecting outcomes in a large cohort of SDC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We selected 304 SDC cases and investigated clinical characteristics and the factors affecting outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The median age of the cases examined was 68\u2009years, the most common primary site was the parotid gland (238 cases), and there was a male predominance (M\/F\u00a0=\u00a05:1). Outcomes were significantly worse when the primary tumor site was the minor salivary glands (SG) than when it was the major SG. Outcomes were also significantly worse in pN(+) cases (161 cases) than in pN0 cases, particularly those with a metastatic lymph node number \u226511. The cumulative incidence of relapse and distant metastases was significantly higher in stage IV cases than in stage 0\u2013III cases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The absolute number of lymph node metastases, higher stages, and the minor SG as the primary tumor site were identified as factors affecting the outcome of SDC.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.27034","type":"journal-article","created":{"date-parts":[[2022,3,30]],"date-time":"2022-03-30T05:40:13Z","timestamp":1648618813000},"page":"1430-1441","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["The implicated clinical factors for outcomes in 304 patients with salivary duct carcinoma: Multi\u2010institutional retrospective analysis in Japan"],"prefix":"10.1002","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5315-2540","authenticated-orcid":false,"given":"Kimihide","family":"Kusafuka","sequence":"first","affiliation":[{"name":"Department of Pathology Shizuoka General Hospital  Shizuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoko","family":"Sato","sequence":"additional","affiliation":[{"name":"Division of Clinical Biostatistics, Research Support Center Shizuoka General Hospital  Shizuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eiji","family":"Nakatani","sequence":"additional","affiliation":[{"name":"Division of Clinical Biostatistics, Research Support Center Shizuoka General Hospital  Shizuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satoshi","family":"Baba","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Pathology Hamamatsu University School of Medicine Hospital  Shizuoka 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