{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T06:41:35Z","timestamp":1768286495603,"version":"3.49.0"},"reference-count":24,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2022,3,22]],"date-time":"2022-03-22T00:00:00Z","timestamp":1647907200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2022,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Gabapentin has been shown to reduce opioid use in head and neck cancer patients. Here, we examine the efficacy of prophylactic gabapentin at reducing opioid use in these patients at our institution.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective study of patients receiving radiation was performed, using patients from our previous study as controls. Risk factors for opioid use at 3 and 6\u2009months were determined using univariate and multivariate analyses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In total, 53\/185 patients were treated with gabapentin, 39.6% of which took opioids at 3\u00a0months vs. 58.3% in the non\u2010gabapentin cohort (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.021). Gabapentin was independently associated with less opioid use on multivariate analysis at 3\u00a0months (OR 0.47, 95% CI 0.24\u20130.9). Gastrostomy tube dependence and pretreatment opioid use were associated with chronic opioid use despite gabapentin.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Gabapentin is effective at expediting opioid tapering in head and neck cancer patients who are not gastrostomy tube dependent or taking opioids pretreatment.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.27035","type":"journal-article","created":{"date-parts":[[2022,3,22]],"date-time":"2022-03-22T12:19:22Z","timestamp":1647951562000},"page":"1368-1376","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Effectiveness of gabapentin in reducing opioid requirements after radiation in head and neck cancer in a single institution"],"prefix":"10.1002","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2421-3847","authenticated-orcid":false,"given":"David R.","family":"Gilley","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2014Head and Neck Surgery University of Missouri School of Medicine Columbia Missouri USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew D.","family":"Clark","sequence":"additional","affiliation":[{"name":"Department of General Surgery University of Missouri School of Medicine Columbia Missouri USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maggie E.","family":"Wieser","sequence":"additional","affiliation":[{"name":"Degree Program University of Missouri School of Medicine Columbia Missouri USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9514-5338","authenticated-orcid":false,"given":"Craig A.","family":"Bollig","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2014Head and Neck Surgery Rutgers Robert Wood Johnson Medical School New Brunswick New Jersey USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura M.","family":"Dooley","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2014Head and Neck Surgery University of Missouri School of Medicine Columbia Missouri USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gregory B.","family":"Biedermann","sequence":"additional","affiliation":[{"name":"Department of Radiology, Division of Radiation Oncology, Ellis Fischel Cancer Center University of Missouri School of Medicine Columbia Missouri USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,3,22]]},"reference":[{"key":"e_1_2_8_2_1","volume-title":"The Joint Commission's Pain Standards: Origins and Evolution","author":"Baker DW","year":"2017"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinthera.2013.10.001"},{"key":"e_1_2_8_4_1","unstructured":"National Center for Health Statistics.Wide\u2010Ranging Online 626. 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