{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T06:54:28Z","timestamp":1768892068046,"version":"3.49.0"},"reference-count":29,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2022,4,11]],"date-time":"2022-04-11T00:00:00Z","timestamp":1649635200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Tumor\u2010associated macrophages in the tumor microenvironment (TME), as a factor affecting lymphocytes, have received much attention. Both lymphocytes and macrophages can switch the expression of histamine receptors. In this study, we investigated the role of histamine in the TME of tongue squamous cell carcinoma (SCC).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Sixty\u2010seven patients with stage I tongue SCC were studied. Histamine was evaluated by the expression of L\u2010histidine decarboxylase (HDC). Macrophages, T lymphocytes, and lymph vessel density, as well as the Ki\u201067 labeling index (LI) and depth of invasion (DOI), were compared with HDC expression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>HDC expression was significantly affected by the TME. The DOI, worst pattern of invasion, and Ki\u201067 LI were associated with histamine expression. C\u2010C motif chemokine ligand (CCL) 2 and CCL22 were co\u2010expressed with histamine H1 and H2 receptors. Histamine expression was most affected by the DOI.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Tongue SCC expressing histamine affected the TME via histamine receptors and chemokines.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.27056","type":"journal-article","created":{"date-parts":[[2022,4,12]],"date-time":"2022-04-12T06:20:25Z","timestamp":1649744425000},"page":"1554-1562","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Relationship of histamine expression with chemokine balance in the tumor microenvironment of squamous cell carcinoma of the tongue"],"prefix":"10.1002","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5038-9064","authenticated-orcid":false,"given":"Satoshi","family":"Kimura","sequence":"first","affiliation":[{"name":"Department of Clinical Pathology Kitakyushu City Yahata Hospital  Kitakyushu Japan"},{"name":"Department of Pathology, School of 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