{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T23:37:12Z","timestamp":1790811432596,"version":"4.1.0"},"reference-count":18,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2022,4,15]],"date-time":"2022-04-15T00:00:00Z","timestamp":1649980800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>This study aimed to evaluate the accuracy and oncological results of sentinel lymph node biopsy in patients with early lip and oral cavity squamous cell carcinoma (SCC) in a real\u2010world scenario.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Retrospective study including seven Brazilian centers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Four\u2010hundred and seven cN0 patients were accrued for 20\u2009years. The rate of occult metastasis was 23.1% and 22 patients (5.4%) had regional failure. We found, for 5\u2009years of follow\u2010up, 85.3% of regional recurrence\u2010free survival; 77.1% of disease\u2010free survival; 73.7% of overall survival; and 86.7% of disease\u2010specific survival. The rate of false\u2010negative cases was 5.4%.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In a real\u2010world scenario, sentinel lymph node biopsy for patients with SCC of the lip and oral cavity proved feasible in different settings and to be oncologically safe, with similar rates of occult lymph node metastasis and false\u2010negative cases, when compared to elective neck dissection, and with similar long\u2010term survival to that reported historically.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.27061","type":"journal-article","created":{"date-parts":[[2022,4,15]],"date-time":"2022-04-15T16:19:46Z","timestamp":1650039586000},"page":"1604-1615","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Sentinel lymph node biopsy for early squamous cell carcinoma of the lip and oral cavity: Real\u2010world experience in Brazil"],"prefix":"10.1002","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5068-8208","authenticated-orcid":false,"given":"Leandro Luongo","family":"Matos","sequence":"first","affiliation":[{"name":"Department of Head and Neck Surgery Instituto do Cancer do Estado de S\u00e3o Paulo (ICESP), University of S\u00e3o Paulo Medical School, and Faculdade Israelita de Ci\u00eancias da Sa\u00fade Albert Einstein Medical School  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1221-5503","authenticated-orcid":false,"given":"Renato Castro","family":"Capuzzo","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Surgery Barretos Cancer Hospital  Barretos Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola Andrea Galbiatti","family":"Pedruzzi","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Surgery Hospital Erasto Gaertner  Paran\u00e1 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