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However, this information is not readily available in administrative data.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Alberta Cancer Registry, physician claims, and other administrative data were used. Timing of second event was estimated based on our developed algorithm. For validation, the difference, in days between the algorithm estimated and the chart\u2010reviewed timing of second event. Further, the result of Cox\u2010regression modeling cancer\u2010free survival was compared to chart review data.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Majority (74.3%) of the patients had a difference between the chart\u2010reviewed and algorithm\u2010estimated timing of second event falling within the 0\u201360\u2009days window. Kaplan\u2013Meier curves generated from the estimated data and chart review data were comparable with a 5\u2010year second\u2010event\u2010free survival rate of 75.4% versus 72.5%.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The algorithm provided an estimated timing of second event similar to that of the chart review.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.27109","type":"journal-article","created":{"date-parts":[[2022,6,2]],"date-time":"2022-06-02T15:30:04Z","timestamp":1654183804000},"page":"1909-1917","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Validated algorithms for identifying timing of second event of oropharyngeal squamous cell carcinoma using r<scp>eal\u2010world<\/scp> data"],"prefix":"10.1002","volume":"44","author":[{"given":"Shahreen","family":"Khair","sequence":"first","affiliation":[{"name":"Department of Community Health Sciences, Cumming School of Medicine University of Calgary  Calgary Alberta Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0858-187X","authenticated-orcid":false,"given":"Joseph C.","family":"Dort","sequence":"additional","affiliation":[{"name":"Department of Community Health Sciences, Cumming School of Medicine University of Calgary  Calgary Alberta Canada"},{"name":"Department of Surgery, Cumming School of Medicine University of Calgary, North Tower, Foothills Medical Centre  Calgary Alberta Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"May Lynn","family":"Quan","sequence":"additional","affiliation":[{"name":"Department of Community Health Sciences, Cumming School of Medicine University of Calgary  Calgary Alberta Canada"},{"name":"Department of Surgery, Cumming School of Medicine University of Calgary, North Tower, Foothills Medical Centre  Calgary Alberta Canada"},{"name":"Department of Oncology, Cumming School of Medicine University of Calgary, Tom Baker, Cancer Centre  Calgary Alberta Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Winson Y.","family":"Cheung","sequence":"additional","affiliation":[{"name":"Department of Community Health Sciences, Cumming School of Medicine University of Calgary  Calgary Alberta Canada"},{"name":"Department of Surgery, Cumming School of Medicine University of Calgary, North Tower, Foothills Medical Centre  Calgary Alberta Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7658-4351","authenticated-orcid":false,"given":"Khara M.","family":"Sauro","sequence":"additional","affiliation":[{"name":"Department of Community Health Sciences, Cumming School of Medicine University of Calgary  Calgary Alberta Canada"},{"name":"Department of Surgery, Cumming School of Medicine University of Calgary, North Tower, Foothills Medical Centre  Calgary Alberta Canada"},{"name":"Department of Oncology, Cumming School of Medicine 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