{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T14:38:18Z","timestamp":1788964698710,"version":"build-2803163510"},"reference-count":32,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Previous studies have investigated the value of induction chemotherapy (IC) in organ preservation strategies for head and neck cancers. This study evaluated the effectiveness of sequential IC with radiotherapy as a laryngeal preservation strategy for locally advanced hypopharyngeal carcinoma (LAHSCC).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>One hundred and forty\u2010two consecutive patients with LAHSCC were retrospectively analyzed who received three IC regimens from 2015 to 2019.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In the TP (docetaxel plus cisplatin), TPF (TP plus 5\u2010fluorouracil), and TPX (TP plus capecitabine) IC groups, there were 51, 29, and 62 patients, respectively. The primary tumor objective response rates were 51%, 55.2%, and 71%, and the 3\u2010year survival rates with preserved larynx were 36.6%, 31.8%, and 51.2%, respectively (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u20090.03). There was no difference in overall survival and the adverse events were tolerable.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The TPX regimen displayed good efficacy and safety, indicating its potential as a therapeutic IC regimen for LAHSCC.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/hed.27119","type":"journal-article","created":{"date-parts":[[2022,8,2]],"date-time":"2022-08-02T01:50:49Z","timestamp":1659405049000},"page":"2018-2029","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Induction chemotherapy of modified docetaxel, cisplatin, 5\u2010fluorouracil for laryngeal preservation in locally advanced hypopharyngeal squamous cell carcinoma"],"prefix":"10.1002","volume":"44","author":[{"given":"Ruichen","family":"Li","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology, Eye Ear Nose and Throat Hospital Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lulu","family":"Ye","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Fudan University Shanghai Cancer Center  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Eye Ear Nose and Throat Hospital Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Ding","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Eye Ear Nose and Throat Hospital Fudan University  Shanghai 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