{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T08:36:57Z","timestamp":1787647017766,"version":"build-2736575974"},"reference-count":18,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2022,7,11]],"date-time":"2022-07-11T00:00:00Z","timestamp":1657497600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["Intramural funding"],"award-info":[{"award-number":["Intramural funding"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Immune checkpoint blockade can provide clinical benefit for patients with advanced cancer. Here, we report durable disease control over many years following PD\u2010L1 blockade through induction of a viral antigen\u2010specific T cell response in an adult patient with recurrent respiratory papillomatosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Antigen\u2010specific T cell response assays, single cell RNA\u2010sequencing, and RNA\u2010scope was used to study clinical tissues.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>An HPV6 E2\u2010specific T cell clone restricted to HLA\u2010B*55, present at low frequency in the pre\u2010treatment papilloma, significantly expanded after six doses of PD\u2010L1 blockade and remained present and functional at the site of initial response in the larynx as a tissue resident memory T cell for 4\u2009years. An associated reduction in E2 target gene was observed following treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Although demonstrated in a single exceptional responder, these results highlight that immune checkpoint blockade may induce durable, viral antigen\u2010specific immunity of sufficient magnitude to control disease in patients with nonmalignant disorders.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.27144","type":"journal-article","created":{"date-parts":[[2022,7,11]],"date-time":"2022-07-11T10:50:10Z","timestamp":1657536610000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Durable response in a patient with recurrent respiratory papillomatosis treated with immune checkpoint blockade"],"prefix":"10.1002","volume":"44","author":[{"given":"Ke","family":"Bai","sequence":"first","affiliation":[{"name":"Section on Translational Tumor Immunology National Institute on Deafness and Other Communication Disorders, National Institutes of Health  Bethesda Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott M.","family":"Norberg","sequence":"additional","affiliation":[{"name":"Genitourinary Malignancies Branch National Cancer Institute, Center for Cancer Research, National Institutes of Health  Bethesda Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cem","family":"Sievers","sequence":"additional","affiliation":[{"name":"Section on Translational Tumor Immunology National Institute on Deafness and Other Communication Disorders, National Institutes of Health  Bethesda Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tanya","family":"Meyer","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery University of Washington  Seattle Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jay","family":"Friedman","sequence":"additional","affiliation":[{"name":"Section on Translational Tumor Immunology National Institute on Deafness and Other Communication Disorders, National Institutes of Health  Bethesda Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Hinrichs","sequence":"additional","affiliation":[{"name":"Rutgers Cancer Center  New Brunswick New Jersey USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6586-5804","authenticated-orcid":false,"given":"Clint T.","family":"Allen","sequence":"additional","affiliation":[{"name":"Section on Translational Tumor Immunology National Institute on Deafness and Other Communication Disorders, National Institutes of Health  Bethesda Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,7,11]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.29153"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri.2017.112"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40425-019-0603-3"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/jitc-2021-003113"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2019.37.15_suppl.2502"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-199806000-00026"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12865-022-00478-4"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.99488"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms14049"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.4096"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41592-019-0619-0"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.virusres.2016.11.016"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.virol.2011.03.019"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-05072-0"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1136\/jitc-2019-000452"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/s43018-021-00180-1"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.aam6346"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.01861"}],"container-title":["Head &amp; 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