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Interactions among circFNDC3B, miR\u20101322, and MED1 were verified by luciferase reporter and RNA pull\u2010down assays.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The level of circFNDC3B in tissues or cell lines of OTSCC was higher than that in control groups. siRNA\u2010mediated circFNDC3B inhibition resulted in weakened proliferation, migration, and invasion, which was reversed by miR\u20101322. Overexpression of MED1 in OTSCC cells partially reversed the tumor suppression functions of si\u2010circFNDC3B or miR\u20101322 mimics\n                      <jats:italic>in vitro<\/jats:italic>\n                      . circFNDC3B overexpression dramatically promoted tumor growth\n                      <jats:italic>in vivo<\/jats:italic>\n                      . circFNDC3B directly bound with miR\u20101322 and consequently promoted the MED1 expression in OTSCC cells.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The circFNDC3B\/miR\u20101322\/MED1 axis participates in OTSCC progression, which may provide novel therapeutic targets for OTSCC.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/hed.27152","type":"journal-article","created":{"date-parts":[[2022,8,2]],"date-time":"2022-08-02T13:16:37Z","timestamp":1659446197000},"page":"2417-2427","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Overexpression of\n                    <scp>circFNDC3B<\/scp>\n                    promotes the progression of oral tongue squamous cell carcinoma through the\n                    <scp>miR<\/scp>\n                    \u20101322\/\n                    <scp>MED1<\/scp>\n                    axis"],"prefix":"10.1002","volume":"44","author":[{"given":"Xiao","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Medical Oncology The First Affiliated Hospital of Kunming Medical University  Kunming Yunnan Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deyu","family":"Kong","sequence":"additional","affiliation":[{"name":"Department of Medical 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