{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,8]],"date-time":"2026-02-08T23:15:09Z","timestamp":1770592509276,"version":"3.49.0"},"reference-count":34,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2022,8,11]],"date-time":"2022-08-11T00:00:00Z","timestamp":1660176000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2022,8,11]],"date-time":"2022-08-11T00:00:00Z","timestamp":1660176000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>We report outcomes among patients with T2 and select T3 glottic squamous cell carcinoma (SCC) treated with radiotherapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We reviewed T2 and T3 (only paraglottic space invasion) N0 M0 glottic SCC patients treated with curative\u2010intent hypofractionated larynx radiotherapy, with or without concurrent systemic therapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Of 71 patients, those who received concurrent chemotherapy (23\/71; 32%) had worse prognostic factors, including impaired cord mobility (70% vs. 40%,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.02) and larger median gross tumor volume (3.0 vs. 1.6\u00a0cm\n                      <jats:sup>3<\/jats:sup>\n                      ,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.003). Over a median follow\u2010up of 3.8\u2009years, 2\u2010year local control\u00a0among patients with impaired cord mobility appeared higher for those who received chemotherapy (88% vs. 61%,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.12), but the difference was not statistically significant. Acute and late toxicity rates were not higher among patients who received chemotherapy.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The addition of concurrent platinum\u2010based chemotherapy to hypofractionated larynx radiotherapy among patients with early\u2010stage glottic SCC with impaired cord mobility appears safe and worthy of additional investigation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/hed.27165","type":"journal-article","created":{"date-parts":[[2022,8,11]],"date-time":"2022-08-11T03:48:59Z","timestamp":1660189739000},"page":"2513-2521","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Early\u2010stage vocal cord cancer treated with hypofractionated radiotherapy to the larynx with or without concurrent chemotherapy"],"prefix":"10.1002","volume":"44","author":[{"given":"Alexandra N.","family":"de Leo","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology University of Florida College of Medicine  Gainesville Florida USA"},{"name":"Department of Radiation Oncology, University of Florida College of Medicine  Jacksonville USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8747-2710","authenticated-orcid":false,"given":"Roi","family":"Dagan","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology University of Florida College of Medicine  Gainesville Florida USA"},{"name":"Department of Radiation Oncology, University of Florida College of Medicine  Jacksonville USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher G.","family":"Morris","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology University of Florida College of Medicine  Gainesville Florida USA"},{"name":"Department of Radiation Oncology, University of Florida College of Medicine  Jacksonville USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1412-7155","authenticated-orcid":false,"given":"Adam L.","family":"Holtzman","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology University of Florida College of Medicine  Gainesville Florida USA"},{"name":"Department of Radiation Oncology, University of Florida College of Medicine  Jacksonville USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0445-9452","authenticated-orcid":false,"given":"Kathryn E.","family":"Hitchcock","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology University of Florida College of Medicine  Gainesville Florida USA"},{"name":"Department of Radiation Oncology, University of Florida College of Medicine  Jacksonville 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M.","family":"Mendenhall","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology University of Florida College of Medicine  Gainesville Florida USA"},{"name":"Department of Radiation Oncology, University of Florida College of Medicine  Jacksonville 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