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The effect of adjuvant radiotherapy on 5\u2010year locoregional recurrence and disease\u2010specific survival (DSS) was calculated using the Kaplan\u2013Meier method, Wilcoxon rank sum test, and Cox proportional hazards model.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There were no significant differences in locoregional recurrence and DSS between patients receiving adjuvant radiotherapy and those not in both univariate and multivariable analysis. Although patients with positive margin status had a higher locoregional recurrence and those with moderate\/poor differentiation had a worse DSS, stratified analysis still indicated there were no protective effects from the use of adjuvant radiotherapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The use of adjuvant radiation therapy was not associated with improved locoregional recurrence and DSS, even for those with high\u2010risk histopathological factors.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.27203","type":"journal-article","created":{"date-parts":[[2022,9,27]],"date-time":"2022-09-27T09:29:26Z","timestamp":1664270966000},"page":"2865-2874","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["The effect of adjuvant radiotherapy on clinical outcomes in early major salivary gland cancer"],"prefix":"10.1002","volume":"44","author":[{"given":"Wei\u2010Ju","family":"Hong","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology Chi Mei Medical Center  Tainan Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shih\u2010Lun","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology \u2013 Head and Neck Surgery Chi\u2010Mei Medical Center  Tainan Taiwan"},{"name":"Department of Optometry Chung Hwa University of Medical Technology  Tainan Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chia\u2010Jen","family":"Tsai","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Chi Mei Medical Center  Tainan Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hung\u2010Chang","family":"Wu","sequence":"additional","affiliation":[{"name":"Division of Hematology and Oncology, Department of Internal Medicine Chi Mei Medical Center  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