{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T05:56:46Z","timestamp":1761631006182,"version":"3.40.5"},"reference-count":22,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,10,12]],"date-time":"2022-10-12T00:00:00Z","timestamp":1665532800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["FIS PI19\/01661"],"award-info":[{"award-number":["FIS PI19\/01661"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The aim of the current study is to perform an external validation of the prognostic capacity of the H\u2010index in patients with head and neck squamous cell carcinoma (HNSCC).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Retrospective study of 835 patients with HNSCC located in the oral cavity, oropharynx, hypopharynx, or larynx.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>When applying the cutoffs proposed in the original description of the H\u2010index (1.5 and 3.5), we observed an orderly and significant decrease in the disease\u2010specific survival and overall survival as H\u2010index increased. Additionally, we were able to observe a decrease in survival as the H\u2010index increased regardless of the location, the extension of the tumor or the type of treatment performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>We have validated the prognostic capacity of the H\u2010index in patients with HNSCC regardless of the location of the primary tumor, the extent of the disease, or the type of treatment performed.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.27224","type":"journal-article","created":{"date-parts":[[2022,10,13]],"date-time":"2022-10-13T06:03:45Z","timestamp":1665641025000},"page":"178-186","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["External validation of the H\u2010index (host index) in patients with head and neck squamous cell carcinomas"],"prefix":"10.1002","volume":"45","author":[{"given":"Aina","family":"Sansa","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology, Hospital Parc Taul\u00ed Universitat Aut\u00f2noma de Barcelona  Sabadell Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3397-2888","authenticated-orcid":false,"given":"Cristina","family":"Valero","sequence":"additional","affiliation":[{"name":"Head and Neck Service, Department of Surgery Memorial Sloan Kettering Cancer Center  New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7478-8561","authenticated-orcid":false,"given":"Anna","family":"Holgado","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Hospital de la Santa Creu i Sant Pau Universitat Aut\u00f2noma de Barcelona  Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosselin","family":"V\u00e1squez","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Hospital de la Santa Creu i Sant Pau Universitat Aut\u00f2noma de Barcelona  Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miquel","family":"Quer","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Hospital de la Santa Creu i Sant Pau Universitat Aut\u00f2noma de Barcelona  Barcelona Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Bioingenier\u00eda Biomateriales y Nanomedicina (CIBER\u2010BBN)  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Snehal G.","family":"Patel","sequence":"additional","affiliation":[{"name":"Head and Neck Service, Department of Surgery Memorial Sloan Kettering Cancer Center  New York New York 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