{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T15:09:08Z","timestamp":1747148948399,"version":"3.40.5"},"reference-count":14,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,10,27]],"date-time":"2022-10-27T00:00:00Z","timestamp":1666828800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Larynx preservation protocols (LPP) for glottic primary squamous cell carcinoma has gained popularity worldwide. Direct laryngoscopy (DL) with biopsy is mandated when recurrence is suspected. The efficacy of 18Fluoro\u2010deoxy\u2010glucose positron emission computerized tomography (PET\u2010CT) as alternative first\u2010line diagnostic investigation in suspected recurrence was evaluated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective study of patients with suspicious fiber\u2010optic findings at more than 12\u2009weeks after LPP. Sensitivity, specificity, and the negative predictive value (NPV) of DL and PET\u2010CT were compared.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Seventy\u2010two patients presenting 105 cases of suspicious events were included in this study. Fifty\u2010two events were initially investigated by DL and 53 events by PET\u2010CT. The sensitivity of DL and PET\u2010CT was 56.25% and 100%, respectively. The NPV was 84% for DL and 100% for PET\u2010CT (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.015).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Negative PET scans after LPP are highly accurate in ruling out recurrent\/persistent disease and may spare the patient from negative biopsies.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.27227","type":"journal-article","created":{"date-parts":[[2022,10,27]],"date-time":"2022-10-27T13:28:51Z","timestamp":1666877331000},"page":"207-211","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Diagnostic efficacy of positron emission computerized tomography scans in suspicious laryngeal findings <scp>postorgan<\/scp> preservation treatment"],"prefix":"10.1002","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8163-5291","authenticated-orcid":false,"given":"Anton","family":"Warshavsky","sequence":"first","affiliation":[{"name":"Department of Otolaryngology \u2013 Head &amp; Neck Surgery and Maxillofacial Surgery Sackler School of Medicine, Tel\u2010Aviv University  Tel\u2010Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ariel","family":"Holan","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology \u2013 Head &amp; Neck Surgery and Maxillofacial Surgery Sackler School of Medicine, Tel\u2010Aviv University  Tel\u2010Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nidal","family":"Muhanna","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology \u2013 Head &amp; Neck Surgery and Maxillofacial Surgery Sackler School of Medicine, Tel\u2010Aviv University  Tel\u2010Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7765-151X","authenticated-orcid":false,"given":"Yael","family":"Oestraicher","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology \u2013 Head &amp; Neck Surgery and Maxillofacial Surgery Sackler School of Medicine, Tel\u2010Aviv University  Tel\u2010Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuval","family":"Nachalon","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology \u2013 Head &amp; Neck Surgery and Maxillofacial Surgery Sackler School of Medicine, Tel\u2010Aviv University  Tel\u2010Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2745-2088","authenticated-orcid":false,"given":"Liyona","family":"Kampel","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology \u2013 Head &amp; Neck Surgery and Maxillofacial Surgery Sackler School of Medicine, Tel\u2010Aviv University  Tel\u2010Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0628-1942","authenticated-orcid":false,"given":"Narin","family":"Nard\u2010Carmel","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology \u2013 Head &amp; Neck Surgery and Maxillofacial Surgery Sackler School of Medicine, Tel\u2010Aviv University  Tel\u2010Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2433-0798","authenticated-orcid":false,"given":"Hen","family":"Chaushu","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology \u2013 Head &amp; Neck Surgery and Maxillofacial Surgery Sackler School of Medicine, Tel\u2010Aviv University  Tel\u2010Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1741-2074","authenticated-orcid":false,"given":"Udi","family":"Shapira","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology \u2013 Head &amp; Neck Surgery and Maxillofacial Surgery Sackler School of Medicine, Tel\u2010Aviv University  Tel\u2010Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5904-1291","authenticated-orcid":false,"given":"Omer","family":"Ungar","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology \u2013 Head &amp; Neck Surgery and Maxillofacial Surgery Sackler School of Medicine, Tel\u2010Aviv University  Tel\u2010Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Orit","family":"Gutfeld","sequence":"additional","affiliation":[{"name":"Institute of Radiotherapy Sackler School of Medicine, Tel\u2010Aviv University  Tel\u2010Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Inna","family":"Ospovat","sequence":"additional","affiliation":[{"name":"Institute of Radiotherapy Sackler School of Medicine, Tel\u2010Aviv University  Tel\u2010Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasmin Natan","family":"Oz","sequence":"additional","affiliation":[{"name":"Institute of Radiotherapy Sackler School of Medicine, Tel\u2010Aviv University  Tel\u2010Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Einat","family":"Even\u2010Sapir","sequence":"additional","affiliation":[{"name":"Institute of Nuclear Medicine, Tel\u2010Aviv Sourasky Medical Center Sackler School of Medicine, Tel\u2010Aviv University  Tel\u2010Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0719-3098","authenticated-orcid":false,"given":"Gilad","family":"Horowitz","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology \u2013 Head &amp; 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