{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T05:59:38Z","timestamp":1772690378737,"version":"3.50.1"},"reference-count":73,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,11,8]],"date-time":"2022-11-08T00:00:00Z","timestamp":1667865600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["MOST 110\u20102628\u2010B\u2010075\u2010020"],"award-info":[{"award-number":["MOST 110\u20102628\u2010B\u2010075\u2010020"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011912","name":"Taipei Veterans General Hospital","doi-asserted-by":"publisher","award":["V110C\u2010054"],"award-info":[{"award-number":["V110C\u2010054"]}],"id":[{"id":"10.13039\/501100011912","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Trifluoperazine (TFP) is a typical antipsychotic primarily used to treat schizophrenia. In this study, we aimed to evaluate whether TFP can be used as a therapeutic agent against nasopharyngeal carcinoma (NPC) and identify its underlying molecular mechanisms.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We used NPC\u2010TW01, TW03, TW04, and BM to assess the anticancer effects of TFP by using cytotoxicity, wound healing, colony formation, and cell invasion assays. An <jats:italic>in vivo<\/jats:italic> animal study was conducted. RNA sequencing combined with Ingenuity Pathways Analysis was performed to identify the mechanism by which TFP influences NPC cells.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Our data revealed that TFP decreased NPC cell viability in a dose\u2010dependent manner. The invasion and migration of NPC tumor cells were inhibited by TFP. An <jats:italic>in vivo<\/jats:italic> study also demonstrated the anticancer effects of TFP. RNA sequencing revealed several anticancer molecular mechanisms following TFP administration.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The antipsychotic drug TFP could be a potential therapeutic regimen for NPC treatment.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.27238","type":"journal-article","created":{"date-parts":[[2022,11,9]],"date-time":"2022-11-09T06:01:35Z","timestamp":1667973695000},"page":"316-328","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Antipsychotic drug trifluoperazine as a potential therapeutic agent against nasopharyngeal carcinoma"],"prefix":"10.1002","volume":"45","author":[{"given":"Chien\u2010Fu","family":"Yeh","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology\u2010Head and Neck Surgery Taipei Veterans General Hospital  Taipei Taiwan"},{"name":"Department of Otorhinolaryngology, School of Medicine National Yang Ming Chiao 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