{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T13:42:27Z","timestamp":1784641347290,"version":"3.55.0"},"reference-count":19,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,11,19]],"date-time":"2022-11-19T00:00:00Z","timestamp":1668816000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100005301","name":"American College of Surgeons","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005301","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004336","name":"Novartis","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004336","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009455","name":"West Virginia University","doi-asserted-by":"publisher","award":["5U54GM104942\u201005"],"award-info":[{"award-number":["5U54GM104942\u201005"]}],"id":[{"id":"10.13039\/100009455","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Tumor\u2010specific molecular imaging in head and neck squamous cell carcinoma (HNSCC) is not well established. Somatostatin receptors (SSTRs) are found in solid tumors, including HNSCC. <jats:sup>68<\/jats:sup>Ga\u2010DOTATATE, a commercially available radionuclide that binds SSTRs, may have utility in imaging HNSCC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients with HNSCC received pretreatment imaging with <jats:sup>18<\/jats:sup>F\u2010FDG\u2010PET\/CT and <jats:sup>68<\/jats:sup>Ga\u2010DOTATATE. Imaging was compared for concordance. When available, surgical resection specimens were compared to pretreatment imaging findings. Historic HNSCC tumor specimens were assessed for both SSTR and p16\/human papilloma virus (HPV) expression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twenty patients were imaged. Fifteen had oropharyngeal cancer. Primary tumor site was concordant between imaging modalities for all patients. One of 45 lymph nodes was discordant. Retrospective specimen review showed a significant correlation with SSTR expression and HPV\/p16 expression. No adverse events occurred.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p><jats:sup>68<\/jats:sup>Ga\u2010DOTATATE imaging is safe and effective in HNSCC. SSTR expression may be increased in HPV\u2010mediated tumors. Targeted therapies to SSTR should be explored.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.27243","type":"journal-article","created":{"date-parts":[[2022,11,19]],"date-time":"2022-11-19T13:50:21Z","timestamp":1668865821000},"page":"347-354","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["<scp><sup>18<\/sup>F<\/scp>\u2010fludeoxyglucose positron emission computed tomography (<scp><sup>18<\/sup>F\u2010FDG\u2010PET<\/scp>\/<scp>CT<\/scp>) versus <scp><sup>68<\/sup>Ga\u2010DOTATATE\u2010PET<\/scp>\/<scp>CT<\/scp> in patients with head and neck cancer: Comparisons and implications for treatment"],"prefix":"10.1002","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1553-6951","authenticated-orcid":false,"given":"Rusha","family":"Patel","sequence":"first","affiliation":[{"name":"Department of Otolaryngology Oklahoma University  Oklahoma City Oklahoma United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary","family":"Marano","sequence":"additional","affiliation":[{"name":"Department of Radiology West Virginia University  Morgantown West Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joe","family":"Joseph","sequence":"additional","affiliation":[{"name":"Department of Radiology West Virginia University  Morgantown West Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffson","family":"Chung","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology West Virginia University  Morgantown West Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Plata","sequence":"additional","affiliation":[{"name":"Department of Pathology West Virginia University  Morgantown West Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey A.","family":"Vos","sequence":"additional","affiliation":[{"name":"Department of Pathology West Virginia University  Morgantown West Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,11,19]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599817742579"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.1146"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2273.2003.00711.x"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13000\u2010016\u20100461\u2010y"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0171301"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-013-2442-7"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.24164"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0090-8258(03)00078-7"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.18.19881"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12149-020-01494-3"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/RLU.0000000000003421"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.2967\/jnmt.120.258343"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/RLU.0000000000003555"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1177\/23247096211035232"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0037-1616490"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/RLU.0b013e31820aa2a8"},{"key":"e_1_2_7_18_1","unstructured":"MarrTJ LenzoNP GillA et al.High sensitivity and specificity of Ga68 Octreotate PET compared with F\u201018 FDG PET in head and neck squamous cell carcinoma.http:\/\/theranostics.com.au\/wp-content\/uploads\/2016\/05\/Ga-68-Head-Neck-ANZSNM-Imaging.pdf"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.111.091165"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1148\/rg.352140164"}],"container-title":["Head &amp; 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