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However, contradictory findings have also been published. We aimed to clarify the effect of NLR on the prognosis of hypopharyngeal cancer through meta\u2010analysis. Systematic search of PubMed and other database with study selection and data extraction. The combined hazard ratio (HR) and 95% confidence intervals (CI) were calculated using STATA, applying either a fixed\u2010effects or random\u2010effects model. Meta\u2010regression, subgroup analysis, and sensitivity analysis were used to analyze sources of heterogeneity. Publication bias were also assessed. This meta\u2010analysis included 2232 patients with hypopharyngeal cancer from seven studies. The combined HR (OS, HR\u00a0=\u00a01.80, 95CI%, 1.14\u20132.82; PFS, HR\u00a0=\u00a01.88, 95CI%, 1.26\u20132.79) suggested that high NLR was associated with poor overall survival (OS) and progression\u2010free survival (PFS). Pretreatment NLR can be used as an effective serological indicator to assess the prognosis of patients with hypopharyngeal cancer.<\/jats:p>","DOI":"10.1002\/hed.27246","type":"journal-article","created":{"date-parts":[[2022,11,11]],"date-time":"2022-11-11T13:02:43Z","timestamp":1668171763000},"page":"492-502","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Neutrophil\u2010to\u2010lymphocyte and hypopharyngeal cancer prognosis: System review and meta\u2010analysis"],"prefix":"10.1002","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9163-509X","authenticated-orcid":false,"given":"Xianyang","family":"Hu","sequence":"first","affiliation":[{"name":"Department of Otolaryngology \u2013 Head and Neck Surgery Eye Ear Nose and Throat Hospital, Fudan University  Shanghai China"},{"name":"School of Basic Medical Sciences Shanghai Medical College of Fudan University  Shanghai 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