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Specifically, 2\u2010, 3\u2010, and 5\u2010year overall survival were the primary outcome. A total of 89 studies with 101 cohorts were collected. Endoscopic nasopharyngectomy was found to be associated with a significantly improved 5\u2010year OS compared with CRT (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.027) and IMRT (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.016). Moreover, based on recurrence T classification, the 2\u2010, 3\u2010, and 5\u2010year OS were similar across different treatments. Endoscopic nasopharyngectomy was associated with a significant reduction in treatment\u2010related complications (grade\u2009\u2265\u20093) compared with IMRT (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) and open nasopharyngectomy (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.028). Endoscopic nasopharyngectomy may provide comparable treatment outcomes to re\u2010irradiation, while offering a better safety profile for selective patients with resectable IrNPC.<\/jats:p>","DOI":"10.1002\/hed.27253","type":"journal-article","created":{"date-parts":[[2022,11,24]],"date-time":"2022-11-24T18:12:47Z","timestamp":1669313567000},"page":"503-520","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Salvage treatments for locally recurrent nasopharyngeal cancer: Systematic review and meta\u2010analysis"],"prefix":"10.1002","volume":"45","author":[{"given":"Dong","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery The Central Hospital of Dazhou Dazhou Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mange","family":"Liao","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck 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