{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T17:41:32Z","timestamp":1792086092835,"version":"4.4.0"},"reference-count":16,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,12,13]],"date-time":"2022-12-13T00:00:00Z","timestamp":1670889600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>This study evaluates the impact of depth of invasion (DOI) on local recurrence (LR) in node\u2010negative oral tongue squamous cell carcinoma (SCC).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Fifty\u2010one patients were retrospectively reviewed from an institutional database. Patients were evaluated for local control (LC). Cox\u2010proportional hazards modeling was used to calculate hazard ratios.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There were 84.3% T1\/2 and 15.7% T3\/4 classification tumors. The 3\u2010year overall survival rate was 97.9%. Local failure rate was 5.7% with a 3\u2010year LC of 93.6%. On Univariate analysis, increased hazard of LR was noted with each unit increase in DOI (HR 1.40, 95% CI 1.07\u20131.83, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.014). Age, sex, T classification, margins \u22655\u2009mm, lymphovascular invasion (LVI) and perineural invasion (PNI), and adjuvant treatment were not associated with LR. On Multivariate analysis, adjusting for age and adjuvant treatment, results for DOI remained significant (aHR 1.46, 95% CI 1.08\u20131.98, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.013).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>On evaluation of our institutional dataset increasing DOI was associated with increased hazard of local recurrence with oral tongue SCC.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.27264","type":"journal-article","created":{"date-parts":[[2022,12,14]],"date-time":"2022-12-14T02:48:55Z","timestamp":1670986135000},"page":"561-566","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Impact of depth of invasion on local recurrence in <scp>R0<\/scp> resected node\u2010negative oral tongue squamous cell carcinoma"],"prefix":"10.1002","volume":"45","author":[{"given":"Rushil R.","family":"Dang","sequence":"first","affiliation":[{"name":"Division of Maxillofacial Oncology and Reconstructive Surgery, Department of Oral and Maxillofacial Surgery Boston Medical Center  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaegak","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery Boston Medical Center  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad M.","family":"Qureshi","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Boston Medical center  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shoreh Roghayeh","family":"Fazeli","sequence":"additional","affiliation":[{"name":"Department of Pathology Beth Israel Deaconess Medical Center  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Anatomic Pathology Boston Medical Center  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vikki L.","family":"Noonan","sequence":"additional","affiliation":[{"name":"Division of Oral and Maxillofacial Pathology Boston University Henry M. Goldman School of Dental Medicine  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Devaki","family":"Sundararajan","sequence":"additional","affiliation":[{"name":"Division of Oral and Maxillofacial Pathology Boston University Henry M. Goldman School of Dental Medicine  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Salama","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery Long Island Jewish Medical Center  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6662-4981","authenticated-orcid":false,"given":"Minh Tam","family":"Truong","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Boston University School of Medicine  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,12,13]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21654"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.24589"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2008.06.002"},{"key":"e_1_2_8_5_1","unstructured":"National Cancer Institute.Surveillance Epidemiology and End Results (SEER).https:\/\/seer.cancer.gov\/statistics. 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