{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T09:36:01Z","timestamp":1785836161914,"version":"3.56.0"},"reference-count":26,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,1,4]],"date-time":"2023-01-04T00:00:00Z","timestamp":1672790400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003392","name":"Natural Science Foundation of Fujian Province","doi-asserted-by":"publisher","award":["2020J01970"],"award-info":[{"award-number":["2020J01970"]}],"id":[{"id":"10.13039\/501100003392","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017686","name":"Fujian Provincial Health Technology Project","doi-asserted-by":"publisher","award":["2019\u2010ZQN\u201052"],"award-info":[{"award-number":["2019\u2010ZQN\u201052"]}],"id":[{"id":"10.13039\/501100017686","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>To investigate the effect of nutritional status on radiation\u2010induced acute toxicities in nasopharyngeal carcinoma (NPC) patients before radiotherapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Nutritional status of 228 patients with NPC who received intensity\u2010modulated radiotherapy was retrospectively analyzed by modified nutrition index (m\u2010NI). Cumulative grading score of six common acute toxicities were defined as total score for acute toxicities.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>M\u2010NI \u22646 is a risk factor for xerostomia (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.016, OR\u00a0=\u00a00.208, 95% CI 0.058\u20130.743), oral mucositis (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.016, OR\u00a0=\u00a00.287, 95% CI 0.104\u20130.793), dysgeusia (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.001, OR\u00a0=\u00a00.028, 95% CI 0.004\u20130.217), and dysphagia (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.015, OR\u00a0=\u00a00.251, 95% CI 0.083\u20130.764) as well in patients with NPC. Total score of radiation\u2010induced acute toxicities of patients with malnutrition (13.6\u2009\u00b1\u20091.7) was significantly higher than that of patients with normal nutrition (12.0\u2009\u00b1\u20092.4) (<jats:italic>t<\/jats:italic>\u00a0=\u00a0\u22125.464, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>NPC patients with malnutrition before radiotherapy develop more serious dysgeusia, oral mucositis, dysphagia, and xerostomia after intensity\u2010modulated radiotherapy.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.27275","type":"journal-article","created":{"date-parts":[[2023,1,5]],"date-time":"2023-01-05T05:28:51Z","timestamp":1672896531000},"page":"620-628","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Effect of nutritional status before radiotherapy on radiation\u2010induced acute toxicities in patients with nasopharyngeal carcinoma"],"prefix":"10.1002","volume":"45","author":[{"given":"Xiurong","family":"Song","sequence":"first","affiliation":[{"name":"Department of Radiotherapy, Cancer Center The First Affiliated Hospital of Fujian Medical University  Fuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Su","sequence":"additional","affiliation":[{"name":"Department of Radiotherapy, Cancer Center The First Affiliated Hospital of Fujian Medical University  Fuzhou China"},{"name":"Key Laboratory of Radiation Biology of Fujian Higher Education Institutions The First Affiliated Hospital of Fujian Medical University  Fuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiaojing","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Radiotherapy, Cancer Center The First Affiliated Hospital of Fujian Medical University  Fuzhou 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