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In the oral cavity, the HR for death for SpCC compared with SCC was 1.33 (<jats:italic>p\u2009&lt;<\/jats:italic>\u00a00.001). In the oropharynx, the HR for death for SpCC compared with SCC was 1.47 (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.028).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>After adjusting for patient, tumor, and treatment characteristics, SpCC histology had an independent adverse prognostic effect on OS in the oral cavity and oropharynx. SpCC histology does not necessarily portend poorer survival in all HNSCC.<\/jats:p><jats:p><jats:bold>Level of Evidence:<\/jats:bold> 4.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.27285","type":"journal-article","created":{"date-parts":[[2022,12,30]],"date-time":"2022-12-30T19:08:47Z","timestamp":1672427327000},"page":"685-696","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Prognostic significance of head and neck spindle cell carcinoma"],"prefix":"10.1002","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0794-041X","authenticated-orcid":false,"given":"Aman M.","family":"Patel","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2014Head and Neck Surgery Rutgers New Jersey Medical School  Newark New Jersey USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hannaan S.","family":"Choudhry","sequence":"additional","affiliation":[{"name":"Department of 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