{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T18:51:40Z","timestamp":1789411900542,"version":"build-2803163510"},"reference-count":30,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,12,23]],"date-time":"2022-12-23T00:00:00Z","timestamp":1671753600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>This study aimed to analyze the prognostic determinants for re\u2010recurrence and malignant transformation of parotid recurrent pleomorphic adenoma (RPA).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Between January 2011 and December 2020, all the cases of RPA of the parotid gland at our single institution were reviewed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 168 patients were included in this study, with a median age of 41.5\u2009years, and 20 (11.9%) patients developed re\u2010recurrence during follow\u2010up. It has been evidenced that recurrence times (single or multiple) was an independent prognostic factor for recurrence\u2010free survival (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.0264). A total of 26 (15.48%) patients experienced malignant transformation of parotid RPA, and older age (&gt;45\u2009year old), male sex, and higher clinical tumor staging (T3\u2013T4) were significantly associated with malignant transformation of parotid RPA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Recurrence times was an independent prognostic factor for re\u2010recurrence of parotid RPA, and older male with high T\u2010stage may more easily develop malignant transformation.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.27286","type":"journal-article","created":{"date-parts":[[2022,12,23]],"date-time":"2022-12-23T20:23:56Z","timestamp":1671827036000},"page":"697-705","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Recurrent pleomorphic adenoma of the parotid gland: A population\u2010based study with emphasis on re\u2010recurrence and malignant transformation"],"prefix":"10.1002","volume":"45","author":[{"given":"Wanlin","family":"Xu","sequence":"first","affiliation":[{"name":"Department of Oral and Maxillofacial\u2010Head and Neck Oncology, Shanghai Ninth People's Hospital Shanghai Jiao Tong University School of Medicine  Shanghai China"},{"name":"College of Stomatology Shanghai Jiao Tong University  Shanghai China"},{"name":"National Center for Stomatology  Shanghai China"},{"name":"National Clinical Research Center for Oral Diseases  Shanghai China"},{"name":"Shanghai Key Laboratory of Stomatology  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xu","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial\u2010Head and Neck Oncology, Shanghai Ninth People's Hospital Shanghai Jiao Tong University School of Medicine  Shanghai China"},{"name":"College of Stomatology Shanghai Jiao Tong University  Shanghai China"},{"name":"National Center for 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