{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T15:05:40Z","timestamp":1789398340437,"version":"build-2803163510"},"reference-count":60,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,12,30]],"date-time":"2022-12-30T00:00:00Z","timestamp":1672358400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>This study aims to investigate the relationship between cancer cachexia and oropharyngeal dysphagia (OD) in patients with head and neck cancer (HNC) prior to chemoradiotherapy or bioradiotherapy (CRT\/BRT).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A prospective cohort study with patients with HNC undergoing CRT\/BRT (2018\u20132021) was conducted. Body composition and skeletal muscle function were evaluated using bioelectrical impedance analysis, handgrip strength, and the short physical performance battery (SPPB). The M. D. Anderson Dysphagia Inventory (MDADI), Eating Assessment Tool (EAT)\u201010 questionnaire, and patient characteristics were collected. A standardized videofluoroscopic swallowing study was offered to patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Sixty\u2010six patients were included. Twenty\u2010six patients scored EAT\u201010\u2009\u2265\u20093 and seventeen were cachectic. ACE\u201027 score &gt;1, cachexia, abnormal SPPB\u2010derived repeated chair\u2010stand test, lower MDADI scores, and higher overall stage grouping showed potential predictive value (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009\u2264\u20090.10) for EAT\u201010\u2009\u2265\u20093. Using multivariable regression analysis, only cachexia remained a significant predictor of EAT\u201010\u00a0\u2265\u20093 (HR 9.000 [95%CI 2.483\u201332.619],\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Cachexia independently predicted the presence of patient\u2010reported OD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/hed.27288","type":"journal-article","created":{"date-parts":[[2022,12,30]],"date-time":"2022-12-30T08:19:40Z","timestamp":1672388380000},"page":"783-797","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Oropharyngeal dysphagia and cachexia: Intertwined in head and neck cancer"],"prefix":"10.1002","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8595-0739","authenticated-orcid":false,"given":"Anna C. H.","family":"Willemsen","sequence":"first","affiliation":[{"name":"GROW School for Oncology and Reproduction Maastricht University Medical Center+  Maastricht The Netherlands"},{"name":"Division of Medical Oncology, Department of Internal Medicine Maastricht University Medical Center+  Maastricht The Netherlands"},{"name":"Department of Respiratory Medicine, NUTRIM School of Nutrition and Translational Research in Metabolism Maastricht University Medical Center+  Maastricht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Walmari","family":"Pilz","sequence":"additional","affiliation":[{"name":"GROW School for Oncology and Reproduction Maastricht University Medical Center+  Maastricht The Netherlands"},{"name":"Department of Otorhinolaryngology \u2013 Head &amp; Neck Surgery Maastricht University Medical Center+  Maastricht The Netherlands"},{"name":"School for Mental Health and Neuroscience \u2013 MHeNs Maastricht University Medical Center+  Maastricht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ann","family":"Hoeben","sequence":"additional","affiliation":[{"name":"GROW School for Oncology and Reproduction Maastricht University Medical Center+  Maastricht The Netherlands"},{"name":"Division of Medical Oncology, Department of Internal Medicine Maastricht University Medical Center+  Maastricht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank J. 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