{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T20:40:57Z","timestamp":1791492057821,"version":"4.3.4"},"reference-count":46,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,2,13]],"date-time":"2023-02-13T00:00:00Z","timestamp":1676246400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Acupuncture is a common part of complementary medicine. However, traditional Chinese acupuncture has been built on concepts which are not in accordance with science\u2010based medicine. Our aim was to critically assess the evidence presented in systematic reviews (SRs) and meta\u2010analyses (MAs) about the effectiveness of acupuncture on radiotherapy induced xerostomia. A systematic search was conducted in February 2022. We evaluated all SRs\/MAs using the AMSTAR\u20102 instrument. Eight SRs, with 12 controlled studies were included. All SRs summarize that the methodological drawbacks do not allow to give a clear statement about the effectiveness of acupuncture. While objective assessments in most SRs\/MAs reported no difference between real and sham acupuncture, some favorable effects on subjective xerostomia symptoms are found. No clinical meaningful effectiveness of acupuncture on xerostomia has been proven so far, but positive subjective findings need to be explored more. While most SRs recommend further studies, studies involving patients with a serious cancer diagnosis are ethically questionable.<\/jats:p>","DOI":"10.1002\/hed.27297","type":"journal-article","created":{"date-parts":[[2023,2,13]],"date-time":"2023-02-13T10:20:09Z","timestamp":1676283609000},"page":"1026-1044","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Umbrella review: Summary of findings for acupuncture as treatment for radiation\u2010induced xerostomia"],"prefix":"10.1002","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2126-6919","authenticated-orcid":false,"given":"Jennifer","family":"D\u00f6rfler","sequence":"first","affiliation":[{"name":"Klinik f\u00fcr Innere Medizin II, H\u00e4matologie und Internistische Onkologie, Universit\u00e4tsklinikum Jena  Jena Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maren","family":"Freuding","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Innere Medizin II, H\u00e4matologie und Internistische Onkologie, Universit\u00e4tsklinikum Jena  Jena Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Zaiser","sequence":"additional","affiliation":[{"name":"Abteilung f\u00fcr Medizinische Statistik, Universit\u00e4tsklinikum Jena  Jena Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jens","family":"B\u00fcntzel","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr HNO\u2010Erkrankungen, Kopf\u2010Hals\u2010Chirurgie, S\u00fcdharz Klinikum Nordhausen  Nordhausen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Keinki","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Innere Medizin II, H\u00e4matologie und Internistische Onkologie, Universit\u00e4tsklinikum Jena  Jena Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lukas","family":"K\u00e4smann","sequence":"additional","affiliation":[{"name":"Abteilung f\u00fcr Radioonkologie, Universit\u00e4tsklinikum, LMU M\u00fcnchen  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jutta","family":"H\u00fcbner","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Innere Medizin II, H\u00e4matologie und Internistische Onkologie, Universit\u00e4tsklinikum Jena  Jena Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,2,13]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.22302"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12903-022-02269-0"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clon.2009.09.002"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.20045"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.5306\/wjco.v10.i1.1"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.21.01208"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/1472-6882-8-37"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/585493"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0032960"},{"key":"e_1_2_11_11_1","unstructured":"Leitlinienprogramm Onkologie S3\u2010Leitlinie Komplement\u00e4rmedizin in der Behandlung onkologischer PatientInnen. 2021 AWMF."},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1089\/acu.2014.1028"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autneu.2010.05.001"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0143-4179(98)90083-X"},{"issue":"4","key":"e_1_2_11_15_1","first-page":"1953","article-title":"Influence of amifostine on late radiation\u2010toxicity in head and neck cancer\u2010a follow\u2010up study","volume":"27","author":"Buentzel J","year":"2007","journal-title":"Anticancer Res"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.j4008"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/0030-4220(92)90124-9"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.2015-0538"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1080\/00016359850136058"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1590\/S1806-83242011000200014"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12906-018-2124-x"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1177\/1534735420980825"},{"key":"e_1_2_11_23_1","first-page":"1","article-title":"Acupuncture for radiation\u2010induced toxicity in head and neck squamous cell carcinoma: a systematic review based on PICO criteria","volume":"279","author":"Bonomo P","year":"2021","journal-title":"Eur Arch Otorhinolaryngol"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2016.12.031"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1136\/aim.2010.002733"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1177\/1534735412451321"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2012.43.5818"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD009603.pub2"},{"key":"e_1_2_11_29_1","first-page":"245","article-title":"Etude contr\u00f4l\u00e9e randomis\u00e9e \u00e9valuant l'action de l'auriculoth\u00e9rapie dans la x\u00e9rostomie induite par la radioth\u00e9rapie des tumeurs de la t\u00eate et du cou","volume":"41","author":"Alimi D","year":"2012","journal-title":"Rev Odontostomatol"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/0964-1955(95)00085-2"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1089\/acm.2007.0793"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2019.16910"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.26550"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2011.12.030"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2009.26.9860"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mds515"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-014-2477-8"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11912-014-0418-9"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oooo.2014.01.229"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.14219\/jada.archive.2008.0353"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1067\/moe.2001.111551"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1741-2358.2007.00137.x"},{"issue":"1","key":"e_1_2_11_43_1","first-page":"12","article-title":"The xerostomia inventory: a multi\u2010item approach to measuring dry mouth","volume":"16","author":"Thomson WM","year":"1999","journal-title":"Community Dent Health"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0360-3016(01)01512-7"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.coc.0000158826.88179.75"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.3109\/02841869409098450"},{"key":"e_1_2_11_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0959-8049(00)00186-6"}],"container-title":["Head &amp; Neck"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hed.27297","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/hed.27297","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hed.27297","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,21]],"date-time":"2023-08-21T14:35:02Z","timestamp":1692628502000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hed.27297"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2,13]]},"references-count":46,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2023,4]]}},"alternative-id":["10.1002\/hed.27297"],"URL":"https:\/\/doi.org\/10.1002\/hed.27297","archive":["Portico"],"relation":{},"ISSN":["1043-3074","1097-0347"],"issn-type":[{"value":"1043-3074","type":"print"},{"value":"1097-0347","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,2,13]]},"assertion":[{"value":"2022-07-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-01-23","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-02-13","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}