{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,20]],"date-time":"2026-06-20T01:52:04Z","timestamp":1781920324273,"version":"3.54.5"},"reference-count":30,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,2,13]],"date-time":"2023-02-13T00:00:00Z","timestamp":1676246400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Radiomics represents an emerging field of precision\u2010medicine. Its application in head and neck is still at the beginning.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Retrospective study about magnetic resonance imaging (MRI) based radiomics in oral tongue squamous cell carcinoma (OTSCC) surgically treated (2010\u20132019; 79 patients). All preoperative MRIs include different sequences (T1, T2, DWI, ADC). Tumor volume was manually segmented and exported to radiomic\u2010software, to perform feature extraction. Statistically significant variables were included in multivariable analysis and related to survival endpoints. Predictive models were elaborated (clinical, radiomic, clinical\u2010radiomic models) and compared using C\u2010index.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In almost all clinical\u2010radiomic models radiomic\u2010score maintained statistical significance. In all cases C\u2010index was higher in clinical\u2010radiomic models than in clinical ones. ADC provided the best fit to the models (C\u2010index 0.98, 0.86, 0.84 in loco\u2010regional recurrence, cause\u2010specific mortality, overall survival, respectively).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>MRI\u2010based radiomics in OTSCC represents a promising noninvasive method of precision medicine, improving prognosis prediction before surgery.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.27299","type":"journal-article","created":{"date-parts":[[2023,2,13]],"date-time":"2023-02-13T10:29:55Z","timestamp":1676284195000},"page":"849-861","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["The role of radiomics in tongue cancer: A new tool for prognosis prediction"],"prefix":"10.1002","volume":"45","author":[{"given":"Chiara","family":"Mossinelli","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology and Head and Neck Surgery European Institute of Oncology, IRCCS  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7879-4846","authenticated-orcid":false,"given":"Marta","family":"Tagliabue","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology and Head and Neck Surgery European Institute of Oncology, IRCCS  Milan Italy"},{"name":"Department of Biomedical Sciences University of Sassari  Sassari Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Ruju","sequence":"additional","affiliation":[{"name":"Division of Radiology IEO, European Institute of Oncology, IRCCS  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulio","family":"Cammarata","sequence":"additional","affiliation":[{"name":"Department of Experimental Oncology IEO European Institute of Experimental Oncology IRCCS  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0498-2964","authenticated-orcid":false,"given":"Stefania","family":"Volpe","sequence":"additional","affiliation":[{"name":"Division of Radiation Oncology European Institute of Oncology, IRCCS  Milan Italy"},{"name":"Department of Oncology and Hemato\u2010Oncology University of Milan  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Raimondi","sequence":"additional","affiliation":[{"name":"Department of Experimental Oncology IEO European Institute of Experimental Oncology IRCCS  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mattia","family":"Zaffaroni","sequence":"additional","affiliation":[{"name":"Division of Radiation Oncology European Institute of Oncology, IRCCS  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes Lars","family":"Isaksson","sequence":"additional","affiliation":[{"name":"Division of Radiation Oncology European Institute of Oncology, IRCCS  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Garibaldi","sequence":"additional","affiliation":[{"name":"Unit of Radiation Research IEO European Institute of Oncology, IRCCS  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Cremonesi","sequence":"additional","affiliation":[{"name":"Unit of Radiation Research IEO European Institute of Oncology, IRCCS  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federica","family":"Corso","sequence":"additional","affiliation":[{"name":"Department of Experimental Oncology IEO European Institute of Experimental Oncology IRCCS  Milan Italy"},{"name":"Department of Mathematics (DMAT) Politecnico di Milano  Milan Italy"},{"name":"Centre for Health Data Science (CHDS) Human Techonopole"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aurora","family":"Gaeta","sequence":"additional","affiliation":[{"name":"Department of Experimental Oncology IEO European Institute of Experimental Oncology IRCCS  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilaria","family":"Emili","sequence":"additional","affiliation":[{"name":"Division of Radiology IEO, European Institute of Oncology, IRCCS  Milan Italy"},{"name":"ASST Centro Specialistico Ortopedico Traumatologico G. 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