{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T06:05:37Z","timestamp":1787724337514,"version":"build-2784847793"},"reference-count":30,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2023,3,8]],"date-time":"2023-03-08T00:00:00Z","timestamp":1678233600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Understanding the impact of surgical treatment on regionally metastatic cutaneous squamous cell carcinoma (cSCC).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Retrospective series of 145 patients undergoing parotidectomy and neck dissection for regionally metastatic cSCC to the parotid. Overall survival (OS), disease\u2010specific survival (DSS), and disease\u2010free survival (DFS) analyzed over 3\u2009years. Multivariate analysis was completed using Cox proportional hazard models.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>OS was 74.5%, DSS was 85.5% and DFS was 64.8%. On multivariate analysis, immune status (HR\u00a0=\u00a03.225[OS], 5.119[DSS], 2.071[DFS]) and lymphovascular invasion (HR\u00a0=\u00a02.380[OS], 5.237[DSS], 2.595[DFS]) were predictive for OS, DSS, and DFS. Margin status (HR\u00a0=\u00a02.296[OS], 2.499[DSS]) and\u2009\u226518 resected nodes (HR\u00a0=\u00a00.242[OS], 0.255[DSS]) were predictive of OS and DSS, while adjuvant therapy was predictive of DSS (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.018).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Immunosuppression and lymphovascular invasion portended worse outcomes in patients with metastatic cSCC to the parotid. Microscopically positive margins and\u2009&lt;18 nodes resected are associated with worse OS and DSS, while patients receiving adjuvant therapy had improved DSS.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.27304","type":"journal-article","created":{"date-parts":[[2023,3,9]],"date-time":"2023-03-09T08:00:46Z","timestamp":1678348846000},"page":"1080-1087","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Surgical factors affecting regionally metastatic cutaneous squamous cell carcinoma to the parotid gland"],"prefix":"10.1002","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0080-7299","authenticated-orcid":false,"given":"Vishwanatha M.","family":"Rao","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2014Head and Neck Surgery Massachusetts Eye and Ear, Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8040-5299","authenticated-orcid":false,"given":"Allen L.","family":"Feng","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2014Head and Neck Surgery Massachusetts Eye and Ear, Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel G.","family":"Deschler","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2014Head and Neck Surgery Massachusetts Eye and Ear, Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Howard L.","family":"Kaufman","sequence":"additional","affiliation":[{"name":"Department of Surgery Massachusetts General Hospital, Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Derrick T.","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2014Head and Neck Surgery Massachusetts Eye and Ear, Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Miller","sequence":"additional","affiliation":[{"name":"Department of Medicine Massachusetts General Hospital, Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeremy D.","family":"Richmon","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2014Head and Neck Surgery Massachusetts Eye and Ear, Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophia Z.","family":"Shalhout","sequence":"additional","affiliation":[{"name":"Department of Medicine Massachusetts General Hospital, Harvard Medical School  Boston Massachusetts 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