{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T22:31:23Z","timestamp":1782340283963,"version":"3.54.5"},"reference-count":37,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,2,20]],"date-time":"2023-02-20T00:00:00Z","timestamp":1676851200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Resected oral cavity carcinoma defects are often reconstructed with osteocutaneous or soft\u2010tissue free flaps, but risk of osteoradionecrosis (ORN) is unknown.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This retrospective study included oral cavity carcinoma treated with free\u2010tissue reconstruction and postoperative IMRT between 2000 and 2019. Risk\u2010regression assessed risk factors for grade\u2009\u22652 ORN.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>One hundred fifty\u2010five patients (51% male, 28% current smokers, mean age 62\u2009\u00b1\u200911\u2009years) were included. Median follow\u2010up was 32.6\u00a0months (range, 1.0\u2013190.6). Thirty\u2010eight (25%) patients had fibular free flap for mandibular reconstruction, whereas 117 (76%) had soft\u2010tissue reconstruction. Grade\u2009\u22652 ORN occurred in 14 (9.0%) patients, at a median 9.8\u00a0months (range, 2.4\u201361.5) after IMRT. Post\u2010radiation teeth extraction was significantly associated with ORN. One\u2010year and 10\u2010year ORN rates were 5.2% and 10%, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>ORN risk was comparable between osteocutaneous and soft\u2010tissue reconstruction for resected oral cavity carcinoma. Osteocutaneous flaps can be safely performed with no excess concern for mandibular ORN.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.27310","type":"journal-article","created":{"date-parts":[[2023,2,20]],"date-time":"2023-02-20T09:54:10Z","timestamp":1676886850000},"page":"890-899","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Rates of osteoradionecrosis in resected oral cavity cancer reconstructed with free tissue transfer in the intensity\u2010modulated radiotherapy era"],"prefix":"10.1002","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0809-9143","authenticated-orcid":false,"given":"Shannon S.","family":"Wu","sequence":"first","affiliation":[{"name":"Cleveland Clinic Lerner College of Medicine  Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanna","family":"Hong","sequence":"additional","affiliation":[{"name":"Cleveland Clinic Lerner College of Medicine  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