{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T16:29:28Z","timestamp":1790872168607,"version":"4.1.0"},"reference-count":18,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2023,3,10]],"date-time":"2023-03-10T00:00:00Z","timestamp":1678406400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Pre\u2010operative embolization prior to surgical resection of carotid body tumors was meant to decrease intraoperative blood loss and operative time. Yet, potential confounders such as different Shamblin classes have never been analyzed. Aim of our meta\u2010analysis was to investigate effectiveness of a pre\u2010operative embolization according to different Shamblin classes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Five studies comprising 245 patients were included. A random effects model meta\u2010analysis was conducted, and the\n                      <jats:italic>I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      statistic was used to assessment for heterogeneity.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Pre\u2010operative embolization was associated with a significant reduction in blood loss (WM: 276.4\u00a0mL; 95% CI, 201.9\u2013378.3,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.01); an absolute mean reduction, though not statistically significant, was observed in both Shamblin 2 and 3 classes. No difference in operative time was found between the two strategies (WM: 192.0\u00a0min; 95% CI, 157.7\u2013234.1,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a01.0).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Embolization proved an overall significant reduction in perioperative bleeding, which did not reach threshold for statistical significance when Shamblin classes were singularly considered.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/hed.27318","type":"journal-article","created":{"date-parts":[[2023,3,10]],"date-time":"2023-03-10T06:15:22Z","timestamp":1678428922000},"page":"1141-1148","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Role of pre\u2010operative embolization in carotid body tumor surgery according to Shamblin classification: A systematic review and meta\u2010analysis"],"prefix":"10.1002","volume":"45","author":[{"given":"Gianluigi","family":"Napoli","sequence":"first","affiliation":[{"name":"Cardiovascular Diseases Section, Department of Interdisciplinary Medicine (DIM) University of Bari  Bari Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rocco","family":"Tritto","sequence":"additional","affiliation":[{"name":"Cardiovascular Diseases Section, Department of Interdisciplinary Medicine (DIM) University of Bari  Bari Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Moscarelli","sequence":"additional","affiliation":[{"name":"Cardiothoracic and Vascular Department Maria Cecilia Hospital GVM Care &amp; Research  Cotignola Ravenna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cinzia","family":"Forleo","sequence":"additional","affiliation":[{"name":"Cardiovascular Diseases Section, Department of Interdisciplinary Medicine (DIM) University of Bari  Bari Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Grazia Carmela","family":"La Marca","sequence":"additional","affiliation":[{"name":"Vascular Surgery Unit \u201cDi Venere\u201d Hospital  Bari Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5459-7373","authenticated-orcid":false,"given":"Lin","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Vascular Surgery The First Affiliated Hospital of Xi'an Jiaotong University  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Biondi\u2010Zoccai","sequence":"additional","affiliation":[{"name":"Department of Medico\u2010Surgical Sciences and Biotechnologies Sapienza University of Rome  Latina Latina Italy"},{"name":"Mediterranea Cardiocentro  Napoli Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arturo","family":"Giordano","sequence":"additional","affiliation":[{"name":"Invasive Cardiology Unit \u201cPineta Grande\u201d Hospital  Castel Volturno Caserta Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yamume","family":"Tshomba","sequence":"additional","affiliation":[{"name":"Unit of Vascular Surgery Fondazione Policlinico Universitario A. Gemelli IRCCS\u2010Universit\u00e0 Cattolica del Sacro Cuore  Roma Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9235-1419","authenticated-orcid":false,"given":"Martino","family":"Pepe","sequence":"additional","affiliation":[{"name":"Cardiovascular Diseases Section, Department of Interdisciplinary Medicine (DIM) University of Bari  Bari Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,3,10]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejvs.2007.01.015"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12105-009-0130-5"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.avsg.2017.03.167"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9610(71)90436-3"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.wneu.2019.05.209"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.avsg.2017.06.149"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.24381"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1177\/1708538116657504"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.13105\/wjma.v5.i4.80"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anl.2014.10.013"},{"issue":"4","key":"e_1_2_9_12_1","first-page":"5318","article-title":"Multi\u2010institutional survey of carotid body tumors in Japan","volume":"15","author":"Ikeda A","year":"2018","journal-title":"Oncol Lett"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.3342\/ceo.2010.3.2.91"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.25387"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.avsg.2020.03.030"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000018824"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599815605323"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1673.2007.01869.x"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2020.04.120"}],"container-title":["Head &amp; Neck"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hed.27318","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/hed.27318","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hed.27318","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,19]],"date-time":"2023-08-19T19:45:23Z","timestamp":1692474323000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hed.27318"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3,10]]},"references-count":18,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2023,5]]}},"alternative-id":["10.1002\/hed.27318"],"URL":"https:\/\/doi.org\/10.1002\/hed.27318","archive":["Portico"],"relation":{},"ISSN":["1043-3074","1097-0347"],"issn-type":[{"value":"1043-3074","type":"print"},{"value":"1097-0347","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,3,10]]},"assertion":[{"value":"2022-09-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-02-02","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-03-10","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}