{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T01:16:18Z","timestamp":1785460578222,"version":"3.56.0"},"reference-count":10,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100020407","name":"Tata Medical Center","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100020407","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The literature on modern\u2010era outcomes of oropharyngeal squamous carcinoma (OPSCC) in India is limited.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>We analyzed records of consecutive patients with OPSCC treated using a curative SIB IMRT regimen of 66\u2009Gy\/30#\/6\u2009weeks.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>One hundred fifteen patients from July 2011 to December 2018 were analyzed. Twenty of 69 patients tested positive for p16. In p16 positive patients, the K\u2010M probability of being disease free and alive at 2\u2009years, with at least one follow\u2010up 3\u00a0months after treatment, was 83% (median not reached) compared with 48% if p16 was unknown\/negative. Patients staged as IVB p16 negative had a 2\u2010year DFS of 25%. Patients unfit for cisplatin and consequently received other agents had 2\u2010year DFS estimated at 20%.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Intensity\u2010modulated radiation therapy (IMRT) with simultaneous integrated boost (SIB) and concurrent chemotherapy was feasible, with toxicity and disease control comparable to available literature. AJCC Stage IVB p16 negative disease had notably poor outcome.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.27328","type":"journal-article","created":{"date-parts":[[2023,3,2]],"date-time":"2023-03-02T05:09:07Z","timestamp":1677733747000},"page":"1156-1161","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Definitive chemoradiation for oropharyngeal squamous carcinomas: Outcomes with intensity\u2010modulated radiation therapy using simultaneous integrated boost, in a majorly p16 negative cohort"],"prefix":"10.1002","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7177-5917","authenticated-orcid":false,"given":"Shaurav","family":"Maulik","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology Tata Medical Center  Kolkata India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paromita","family":"Roy","sequence":"additional","affiliation":[{"name":"Department of Pathology Tata Medical Center  Kolkata India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Indranil","family":"Mallick","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Tata Medical Center  Kolkata India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sriram","family":"Prasath","sequence":"additional","affiliation":[{"name":"Department of Physics Tata Medical Center  Kolkata India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Arun","sequence":"additional","affiliation":[{"name":"Department of Physics Tata Medical Center  Kolkata India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanjoy","family":"Chatterjee","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Tata Medical Center  Kolkata India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,3]]},"reference":[{"issue":"5","key":"e_1_2_8_2_1","first-page":"299","article-title":"HPV in oropharyngeal cancer: the basics to know in clinical practice","volume":"34","author":"Elrefaey S","year":"2014","journal-title":"Acta Otorhinolaryngol Ital"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-020-05979-9"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clon.2019.05.017"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.4103\/sajc.sajc_96_17"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1080\/02841860902845839"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2004.12.004"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2019.11.065"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.30495"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2021.07.1161"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0912217"}],"container-title":["Head &amp; Neck"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hed.27328","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/hed.27328","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hed.27328","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,19]],"date-time":"2023-08-19T23:44:49Z","timestamp":1692488689000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hed.27328"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3]]},"references-count":10,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2023,5]]}},"alternative-id":["10.1002\/hed.27328"],"URL":"https:\/\/doi.org\/10.1002\/hed.27328","archive":["Portico"],"relation":{},"ISSN":["1043-3074","1097-0347"],"issn-type":[{"value":"1043-3074","type":"print"},{"value":"1097-0347","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,3]]},"assertion":[{"value":"2022-06-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-02-06","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-03-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}