{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T22:38:19Z","timestamp":1787006299808,"version":"build-2736575974"},"reference-count":38,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2023,2,28]],"date-time":"2023-02-28T00:00:00Z","timestamp":1677542400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>We aimed to evaluate patients with nasopharyngeal carcinoma (NPC) in a nonendemic population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In a national, retrospective, multicenteric study, 563 patients treated with intensity modulated radiotherapy at 22 centers between 2015 and 2020 were analyzed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Median age was 48 (9\u201383), age distribution was bimodal, 74.1% were male, and 78.7% were stage III\u2010IVA. Keratinizing and undifferentiated carcinoma rates were 3.9% and 81.2%. Patients were treated with concomitant chemoradiotherapy (48.9%), or radiotherapy combined with induction chemotherapy (25%) or adjuvant chemotherapy (19.5%). After 34 (6\u201378) months follow\u2010up, 8.2% locoregional and 8% distant relapse were observed. Three\u2010year overall survival was 89.5% and was lower in patients with age \u226550, male sex, keratinizing histology, T4, N3 and advanced stage (III\u2010IVA).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Patients with NPC in Turkey have mixed clinical features of both east and west. Survival outcomes are comparable to other reported series; however, the rate of distant metastases seems to be lower.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/hed.27333","type":"journal-article","created":{"date-parts":[[2023,2,28]],"date-time":"2023-02-28T23:04:50Z","timestamp":1677625490000},"page":"1194-1205","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["A multicenter retrospective analysis of patients with nasopharyngeal carcinoma treated in\n                    <scp>IMRT<\/scp>\n                    era from a nonendemic population: Turkish Society for Radiation Oncology Head and Neck Cancer Group Study (\n                    <scp>TROD<\/scp>\n                    01\u2010001)"],"prefix":"10.1002","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1412-1933","authenticated-orcid":false,"given":"Halil Cumhur","family":"Yildirim","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology, Cerrahpasa Faculty of Medicine Istanbul University\u2010Cerrahpa\u015fa  Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gulnihan Eren","family":"Kupik","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Faculty of Medicine Mugla Sitki Kocman University  Mugla Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6029-1995","authenticated-orcid":false,"given":"Teuta Zoto","family":"Mustafayev","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Faculty of Medicine Acibadem University  Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tanju","family":"Berber","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Prof Dr. Cemil Tascioglu City Hospital  Istanbul 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