{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T18:46:36Z","timestamp":1761677196326,"version":"3.40.5"},"reference-count":33,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2023,4,11]],"date-time":"2023-04-11T00:00:00Z","timestamp":1681171200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Distant metastasis (DM) development in Oropharyngeal Squamous Cell Carcinoma (OPSCC) represents an important prognostic factor. The identification of a phenotype of metastatic patients may better define therapeutic and follow\u2010up programs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We included 408 patients with OPSCC, non\u2010metastatic at the time of diagnosis, and treated with curative intent. The Overall Survival (OS) analyses were performed and the impact of developing DM on survival was analyzed through Cox proportional\u2010hazard regression model.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>57 (14%) patients develop DM. 302 (74%) were p16+ OPSCC and 35 of them experienced DM. Advanced clinical stage, smoking, p16\u2010status, response to primary treatment, and loco\u2010regional relapse influence the DM rate. Only in the p16+ group, DM onset results in a greater impact on OS (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001). Lung metastases have a better OS compared to non\u2010pulmonary ones (<jats:italic>p<\/jats:italic>\u2009=\u20090.049).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This retrospective study shows a possible stratification of OPSCC patients based on the risk of the development of DMs.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.27354","type":"journal-article","created":{"date-parts":[[2023,4,11]],"date-time":"2023-04-11T19:04:16Z","timestamp":1681239856000},"page":"1406-1417","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Oropharyngeal squamous cell carcinoma: Prognostic factors for development of distant metastases and oncological outcomes"],"prefix":"10.1002","volume":"45","author":[{"given":"Francesco","family":"Mattioli","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology\u2010Head and Neck Surgery University Hospital of Modena  Modena Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2928-2051","authenticated-orcid":false,"given":"Alfredo","family":"Lo Manto","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2010Head and Neck Surgery University Hospital of Modena  Modena Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3398-036X","authenticated-orcid":false,"given":"Matteo","family":"Miglio","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2010Head and Neck Surgery University Hospital of Modena  Modena Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edoardo","family":"Serafini","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2010Head and Neck Surgery University Hospital of Modena  Modena Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Davide","family":"Rossi","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2010Head and Neck Surgery University Hospital of Modena  Modena Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara","family":"Valerini","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2010Head and Neck Surgery University Hospital of Modena  Modena Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberto","family":"Tonelli","sequence":"additional","affiliation":[{"name":"Clinical and Experimental Medicine, Ph.D. Program University of Modena and Reggio Emilia  Modena Italy"},{"name":"Respiratory Diseases Unit and Center for Rare Lung Disease, Department of Surgical and Medical Sciences University Hospital of Modena  Modena Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2727-0321","authenticated-orcid":false,"given":"Matteo","family":"Fermi","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Head and Neck Surgery IRCCS Azienda Ospedaliero\u2010Universitaria di Bologna, Policlinico S. Orsola\u2010Malpighi  Bologna Italy"},{"name":"Department of Specialist Diagnostic and Experimental Medicine (DIMES), Alma Mater Studiorum, Universit\u00e0 di Bologna  Bologna Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppe","family":"Pugliese","sequence":"additional","affiliation":[{"name":"Department of Oncology and Hematology University Hospital of Modena  Modena Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Federica","family":"Bertolini","sequence":"additional","affiliation":[{"name":"Department of Oncology and Hematology University Hospital of Modena  Modena Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisa","family":"D'Angelo","sequence":"additional","affiliation":[{"name":"Radiation Oncology Unit, University Hospital of Modena  Modena Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberta","family":"Depenni","sequence":"additional","affiliation":[{"name":"Department of Oncology and Hematology University Hospital of Modena  Modena Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Massimo","family":"Dominici","sequence":"additional","affiliation":[{"name":"Department of Oncology and Hematology University Hospital of Modena  Modena Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frank R. 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