{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T03:43:26Z","timestamp":1791863006049,"version":"4.3.4"},"reference-count":29,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2023,4,3]],"date-time":"2023-04-03T00:00:00Z","timestamp":1680480000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Collectively, germline pathogenic variants in succinate dehydrogenase (SDH) genes are the most common cause of hereditary paragangliomas. Loss of immunohistochemical expression of SDHB protein (termed SDH deficiency) occurs whenever there is biallelic inactivation of any SDH gene. We sought to estimate the prevalence of SDH deficiency in patients with carotid body paragangliomas.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We identified all carotid body paragangliomas that had undergone surgical excision at our institution over the last 30\u2009years. If SDHB immunohistochemistry was not performed at the time of excision, it was performed on archived material.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There were 64 carotid body paragangliomas identified in the 62 patients. Two\u2010thirds of the patients were female, and 43 (67%) were SDH\u2010deficient.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Up to two\u2010thirds of all carotid body paragangliomas are associated with SDH deficiency. Therefore, genetic testing and counseling should be offered to all patients with carotid body paragangliomas, regardless of age or family history.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.27362","type":"journal-article","created":{"date-parts":[[2023,4,3]],"date-time":"2023-04-03T13:29:21Z","timestamp":1680528561000},"page":"1497-1502","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["<scp>SDH<\/scp> deficiency is very common in carotid body paragangliomas: Genetic counseling and testing should be offered to all patients"],"prefix":"10.1002","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3791-4925","authenticated-orcid":false,"given":"Leba Michael","family":"Sarkis","sequence":"first","affiliation":[{"name":"Department of Otolaryngology, Head and Neck Surgery Royal North Shore Hospital  St Leonards New South Wales 2065 Australia"},{"name":"Sydney Medical School University of Sydney  Sydney New South Wales 2006 Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rory","family":"Clifton\u2010Bligh","sequence":"additional","affiliation":[{"name":"Sydney Medical School University of Sydney  Sydney New South Wales 2006 Australia"},{"name":"Department of Endocrinology Royal North Shore Hospital  St Leonards New South Wales 2065 Australia"},{"name":"Cancer Genetics, Kolling Institute of Medical Research Royal North Shore Hospital  Sydney New South Wales 2065 Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Veivers","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Head and Neck Surgery Royal North Shore Hospital  St Leonards New South Wales 2065 Australia"},{"name":"Sydney Medical School University of Sydney  Sydney New South Wales 2006 Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony James","family":"Gill","sequence":"additional","affiliation":[{"name":"Sydney Medical School University of Sydney  Sydney New South Wales 2006 Australia"},{"name":"NSW Health Pathology, Department of Anatomical Pathology Royal North Shore Hospital  St Leonards New South Wales 2065 Australia"},{"name":"Cancer Diagnosis and Pathology Group, Kolling Institute of Medical Research Royal North Shore Hospital  St Leonards New South Wales 2065 Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,4,3]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.10252"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1308\/147870811X13137608455172"},{"key":"e_1_2_8_4_1","volume-title":"World Health Organization Classification of Tumours. 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