{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T17:22:46Z","timestamp":1790011366943,"version":"4.0.1"},"reference-count":23,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2023,4,12]],"date-time":"2023-04-12T00:00:00Z","timestamp":1681257600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>We investigated the incidence and predictive factors of retropharyngeal lymph node (RPLN) metastases in patients with oropharyngeal cancer (OPC) undergoing multimodality treatment planning imaging before radiotherapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Consecutive patients with OPC treated with curative\u2010intent radiotherapy from 2017 to 2019 were retrospectively analyzed. Treatment planning comprised contrast\u2010enhanced computed tomography (CT), magnetic resonance imaging (MRI), and fluorodeoxyglucose\u2010positron emission tomography (FDG\u2010PET) unless contraindicated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Of 300 patients, 66 (22%) had radiological evidence of RPLN involvement on planning images, compared to 17 (6%) on diagnostic CT alone. On multivariate analysis, RPLN involvement was statistically (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05) associated with tonsil, soft palate, and posterior pharyngeal wall primaries, and with disease extension to the soft palate or vallecula.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Multimodality treatment planning imaging reveals a high rate of RPLN metastases from OPC compared to diagnostic CT alone. Patients with tonsil, soft palate, or posterior pharyngeal wall primaries or disease extending to the soft palate or vallecula appear at higher risk.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/hed.27368","type":"journal-article","created":{"date-parts":[[2023,4,12]],"date-time":"2023-04-12T22:40:36Z","timestamp":1681339236000},"page":"1530-1538","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Incidence and predictive factors of retropharyngeal lymph node metastases in patients with oropharyngeal cancer undergoing multimodality treatment planning imaging"],"prefix":"10.1002","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4459-9196","authenticated-orcid":false,"given":"Danny","family":"Lavigne","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology Centre Hospitalier de l'Universit\u00e9 de Montr\u00e9al (CHUM), University of Montreal  Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mailys","family":"De\u2010Meric\u2010de\u2010Bellefon","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Institut du Cancer de Montpellier  Montpellier France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felix\u2010Phuc","family":"Nguyen\u2010Tan","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Centre Hospitalier de l'Universit\u00e9 de Montr\u00e9al (CHUM), University of Montreal  Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Landry","sequence":"additional","affiliation":[{"name":"Department of Radiology Centre Hospitalier de l'Universit\u00e9 de Montr\u00e9al (CHUM), University of Montreal  Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurent","family":"L\u00e9tourneau\u2010Guillon","sequence":"additional","affiliation":[{"name":"Department of Radiology Centre Hospitalier de l'Universit\u00e9 de Montr\u00e9al (CHUM), University of Montreal  Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manon","family":"B\u00e9lair","sequence":"additional","affiliation":[{"name":"Department of Radiology Centre Hospitalier de l'Universit\u00e9 de Montr\u00e9al (CHUM), University of Montreal  Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian","family":"O'Sullivan","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Centre Hospitalier de l'Universit\u00e9 de Montr\u00e9al (CHUM), University of Montreal  Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edith","family":"Filion","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Centre Hospitalier de l'Universit\u00e9 de Montr\u00e9al (CHUM), University of Montreal  Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Houda","family":"Bahig","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Centre Hospitalier de l'Universit\u00e9 de Montr\u00e9al (CHUM), University of Montreal  Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,4,12]]},"reference":[{"key":"e_1_2_10_2_1","unstructured":"National Comprehensive Cancer Network. 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