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Curative dose escalation is challenging because of adjacent organs at risk, especially in locally advanced cases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Eighteen patients that had locally advanced SB SNACC with unresectable or incomplete surgical resection treated by proton therapy and\/or helical tomotherapy at Institut Curie between 3\/2010 and 8\/2020 were retrospectively included.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>After median follow\u2010up of 52\u2009months, 5\u2010year OS, LRRFS, DMFS, DFS rates were, respectively, 47% (95%CI: 26\u201383), 50% (95%CI: 36\u201388), 39% (95%CI: 26\u201381), 33% (95%CI: 22\u201373). One patient had grade 4 late optic nerve disorder. Eight patients had grade 3 late toxicity including mainly hearing impairments.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Proton therapy and helical tomotherapy are effective and safe methods for curative dose escalation of locally advanced SB SNACC, which are a poor prognosis subgroup. Available literature suggests carbon\u2010ion therapy could be an efficient alternative.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.27371","type":"journal-article","created":{"date-parts":[[2023,4,25]],"date-time":"2023-04-25T13:33:48Z","timestamp":1682429628000},"page":"1619-1631","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Proton therapy and\/or helical tomotherapy for locally advanced sinonasal skull base adenoid cystic carcinoma: Focus on experience of the Institut Curie and review of literature"],"prefix":"10.1002","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4433-6660","authenticated-orcid":false,"given":"Antoine","family":"Mavrikios","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology Institut Curie  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farid","family":"Goudjil","sequence":"additional","affiliation":[{"name":"Proton 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