{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T08:30:28Z","timestamp":1792744228955,"version":"4.5.0"},"reference-count":40,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2023,4,20]],"date-time":"2023-04-20T00:00:00Z","timestamp":1681948800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004606","name":"Chang Gung Medical Foundation","doi-asserted-by":"publisher","award":["CMRPG6L0231"],"award-info":[{"award-number":["CMRPG6L0231"]}],"id":[{"id":"10.13039\/501100004606","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>We aimed to probe the hemoglobin\u2013albumin\u2013lymphocyte\u2013platelet (HALP) score's prognostic value in oral cavity squamous cell carcinoma (OSCC).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Medical data of 350 patients with primary operated OSCC were retrospectively reviewed. We derived the optimal HALP cutoff by executing receiver operating characteristic curve analysis, and patients were then grouped based on this cutoff value. Cox proportional hazards model were used to discover survival outcome\u2010associated factors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We derived the optimal HALP cutoff as 35.4. A low HALP score (&lt;35.4) predicted poorer overall and disease\u2010free survival (hazard ratio: 2.29 and 1.92, respectively; both <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) and was significantly associated with OSCC aggressiveness. We established a HALP\u2010based nomogram that accurately predicted overall survival (concordance index: 0.784).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The HALP score may be a useful prognostic biomarker in patients with OSCC undergoing surgery, and the HALP\u2010based nomogram can be a promising prognostic tool in clinical setting.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.27372","type":"journal-article","created":{"date-parts":[[2023,4,21]],"date-time":"2023-04-21T02:36:07Z","timestamp":1682044567000},"page":"1558-1571","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Prognostic impact of the hemoglobin\u2013albumin\u2013lymphocyte\u2013platelet score in patients with oral cavity cancer undergoing surgery"],"prefix":"10.1002","volume":"45","author":[{"given":"Ku\u2010Hao","family":"Fang","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology \u2013 Head and Neck Surgery Chang Gung Memorial Hospital  Taoyuan Taiwan"},{"name":"College of Medicine Chang Gung University  Taoyuan Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chia\u2010Hsuan","family":"Lai","sequence":"additional","affiliation":[{"name":"College of Medicine Chang Gung University  Taoyuan Taiwan"},{"name":"Department of Radiation Oncology Chang Gung Memorial Hospital  Chiayi Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng\u2010Ming","family":"Hsu","sequence":"additional","affiliation":[{"name":"College of Medicine Chang Gung University  Taoyuan Taiwan"},{"name":"Department of Otorhinolaryngology \u2013 Head and Neck Surgery Chang Gung Memorial Hospital  Chiayi Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun\u2010Ta","family":"Liao","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology \u2013 Head and Neck Surgery Chang Gung Memorial Hospital  Taoyuan 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