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Multivariate analysis was used to determine predictive variables of progression free survival (PFS) and overall survival (OS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Three hundred and eleven patients were included, with median follow\u2010up of 75\u2009months. The most common histologies were squamous cell (42%), adenoid cystic (15%), and sinonasal undifferentiated carcinoma (15%). Induction chemotherapy was administered to 47% of patients; 68% had adjuvant radiotherapy. Ten\u2010year local control, regional control, distant metastasis free survival, PFS, and overall survival rates were 73%, 88%, 47%, 32%, and 51%, respectively. Age, non\u2010nasal cavity tumor site, T3\u20104 stage, neck dissection, and radiation dose were predictive of PFS, while age, non\u2010nasal cavity tumor site, T3\u20104 stage, positive margins, neck dissection, and use of neoadjuvant chemotherapy were predictive of OS. There was a 13% rate of late grade \u22653 toxicities.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This cohort of patients with sinonasal cancer treated with modern radiotherapy demonstrates favorable disease control rate and acceptable toxicity profile.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.27381","type":"journal-article","created":{"date-parts":[[2023,5,11]],"date-time":"2023-05-11T07:10:34Z","timestamp":1683789034000},"page":"1692-1703","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Long\u2010term outcomes of modern multidisciplinary management of sinonasal cancers: The <scp>M. D.<\/scp> Anderson experience"],"prefix":"10.1002","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9508-0602","authenticated-orcid":false,"given":"Houda","family":"Bahig","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology The University of Texas M. D. 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