{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T05:01:05Z","timestamp":1768280465455,"version":"3.49.0"},"reference-count":22,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2023,5,5]],"date-time":"2023-05-05T00:00:00Z","timestamp":1683244800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>To assess the promise of surgical magnification and of intraoperative indocyanine green (ICG) assisted near\u2010infrared fluorescence (NIRF) in improving parathyroid identification and viability assessment during thyroidectomy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Prospective comparative study. Parathyroid gland identification sequentially assessed by naked eye, surgical microscopy, and by NIRF imaging following ICG administration (5\u2009mgIV). Parathyroid perfusion\/vitality reassessed end\u2010surgery by ICG\u2010NIRF.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>An expected total of 104 parathyroid glands were assessed in 35 patients (17 total\u2010thyroidectomy, 18 hemi\u2010thyroidectomy). 54\/104 (51.9%) were identified by naked eye, and sequentially greater numbers identified by microscope magnification (<jats:italic>n<\/jats:italic>\u2009=\u200961; 58.7%; <jats:italic>p<\/jats:italic>\u2009=\u20090.33), and by ICG\u2010NIRF (<jats:italic>n<\/jats:italic>\u2009=\u200972; 69.2%; <jats:italic>p<\/jats:italic>\u2009=\u20090.01). ICG\u2010NIRF detected additional parathyroid glands in 16\/35 patients (45.7%). Confident identification of at least one parathyroid remained unachieved in 5\/35 by naked eye, in 4\/35 by microscopic magnification, and in no patient by ICG\u2010NIRF. ICG\u2010NIRF indicated end\u2010of\u2010surgery devascularization in 12\/72 glands and informed decisions regarding gland implantation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Significantly greater parathyroid glands are identified and preserved with surgical magnification and with ICG\u2010NIRF. Both techniques merit routine adoption for thyroidectomy.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.27387","type":"journal-article","created":{"date-parts":[[2023,5,5]],"date-time":"2023-05-05T08:29:51Z","timestamp":1683275391000},"page":"1753-1760","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Incremental value of magnification and indocyanine green for parathyroid preservation in thyroid surgery"],"prefix":"10.1002","volume":"45","author":[{"given":"Konthoujam","family":"Shaphaba","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology &amp; Head and Neck Surgery All India Institute of Medical Sciences  New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5691-8932","authenticated-orcid":false,"given":"Alok","family":"Thakar","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology &amp; Head and Neck Surgery All India Institute of Medical Sciences  New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6941-9892","authenticated-orcid":false,"given":"Pirabu","family":"Sakthivel","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology &amp; Head and Neck Surgery Kovai Medical Center Hospital  Coimbatore Tamil Nadu India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kapil","family":"Sikka","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology &amp; Head and Neck Surgery All India Institute of Medical Sciences  New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chirom Amit","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology &amp; Head and Neck Surgery All India Institute of Medical Sciences  New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2837-0428","authenticated-orcid":false,"given":"Rajeev","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology &amp; Head and Neck Surgery All India Institute of Medical Sciences  New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ashwin","family":"Chandran","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology &amp; Head and Neck Surgery All India Institute of Medical Sciences  New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ravinder","family":"Goswami","sequence":"additional","affiliation":[{"name":"Department of Endocrinology All India Institute of Medical Sciences  New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,5,5]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s002680010160"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12020-021-02663-8"},{"key":"e_1_2_9_4_1","first-page":"1","article-title":"An audit of the procedure of open thyroidectomy at a tertiary care centre","volume":"74","author":"Monga R","year":"2020","journal-title":"Indian J Otolaryngol Head Neck Surg"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoto.2021.2475"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/coa.12284"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-004-0740-1"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2019.04.072"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.21873\/invivo.11741"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.21037\/gs.2017.05.08"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.25451"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00464-017-5424-1"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1072-7515(02)01310-8"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599814521365"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0032-1327628"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-016-3493-2"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/jso.24237"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.10101"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215110002471"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/cen.13082"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2012.0011"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.21037\/gs.2017.06.13"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules24142560"}],"container-title":["Head &amp; 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