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We summarize the evidence that evaluates locoregional interventions to decrease pain and neck discomfort after thyroidectomy. We designed a scoping review. The search strategy was made in the Pubmed\/MEDLINE and EMBASE database. We included only systematic reviews and RCTs that compared two or more strategies. Forty\u2010nine publications including 5045 patients fulfilled criteria. Sore throat frequency is higher for endotracheal intubation and topical administration of anesthetic before intubation decreases this. Pre\u2010incisional infiltration of the surgical wound decreases postoperative pain. Bilateral superficial plexus nerve block decreases analgesic requirements during and after thyroidectomy. Wound massage and neck exercises decrease postoperative discomfort. Locoregional interventions significantly impact postoperative pain and may reduce opioid use and improve patient outcomes.<\/jats:p>","DOI":"10.1002\/hed.27392","type":"journal-article","created":{"date-parts":[[2023,5,11]],"date-time":"2023-05-11T01:05:23Z","timestamp":1683767123000},"page":"1841-1855","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Locoregional strategies to decrease postoperative pain and neck discomfort after open thyroidectomy: A scoping review"],"prefix":"10.1002","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5563-8840","authenticated-orcid":false,"given":"Alvaro","family":"Sanabria","sequence":"first","affiliation":[{"name":"Department of Surgery Universidad de Antioquia  Medell\u00edn Colombia"},{"name":"CEXCA Centro de Excelencia en Enfermedades de Cabeza y cuello  Medell\u00edn Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"Betancourt","sequence":"additional","affiliation":[{"name":"CEXCA Centro de Excelencia en Enfermedades de Cabeza y cuello  Medell\u00edn Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9454-9464","authenticated-orcid":false,"given":"Carlos","family":"Chiesa\u2010Estomba","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology \u2013 Head &amp; 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