{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T03:45:19Z","timestamp":1784691919476,"version":"3.55.0"},"reference-count":53,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2023,6,12]],"date-time":"2023-06-12T00:00:00Z","timestamp":1686528000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The clinical value of different treatment modalities, especially systemic chemotherapy (CT) in patients with locoregionally advanced olfactory neuroblastoma (LA ONB) remains unclear.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients with LA ONB from 2000 to 2020 at our center were collected retrospectively. The entire cohort was divided into combined systemic and local therapy (CSLT) versus local therapy (LT) groups (grouping method 1), and the same cohort was divided into neoadjuvant chemotherapy (NAC) versus non\u2010NAC groups (grouping method 2). CSLT group included patients treated with CT\u2009+\u2009LT. LT group included patients treated with surgery (SG), radiotherapy (RT), concurrent chemoradiotherapy (CCRT), or any combination of the above methods. LT group was further divided into mono\u2010modality local therapy (MOLT) group and multi\u2010modality local therapy (MULT) group. MOLT group included patients treated with RT alone or SG alone. MULT group included patients treated with SG\u2009+\u2009RT\/CCRT, or CCRT alone. NAC group included patients treated with NAC\u2009+\u2009LT\u2009\u00b1\u2009adjuvant chemotherapy (ADC). Non\u2010NAC group included patients who received LT\u2009\u00b1\u2009ADC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 111 patients with LA ONB were included. The median follow\u2010up was 80.2\u2009months (range, 2.1\u2013254.9). The 5\u2010 and 10\u2010year OS rates were 70.2% and 61.3%, respectively. In univariate analysis, patients treated with NAC (<jats:italic>n<\/jats:italic>\u2009=\u200943) had significantly better overall survival (OS) compared with those without NAC (<jats:italic>n<\/jats:italic>\u2009=\u200968) (<jats:italic>p<\/jats:italic>\u2009=\u20090.041). Patients in MULT group (<jats:italic>n<\/jats:italic>\u2009=\u200945) had significantly improved OS (<jats:italic>p<\/jats:italic>\u2009=\u20090.004) and PFS (<jats:italic>p<\/jats:italic>\u2009=\u20090.003) compared with those in MOLT group (<jats:italic>n<\/jats:italic>\u2009=\u200915). Multivariate analysis identified NAC and CSLT (<jats:italic>n<\/jats:italic>\u2009=\u200951) were independent prognostic factors for superior OS (<jats:italic>p<\/jats:italic>\u2009=\u20090.020, <jats:italic>p<\/jats:italic>\u2009=\u20090.046).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our study suggested that CSLT, especially a combination of NAC and LT, improved the survival of patients with LA ONB. Multiple treatment modalities yielded better PFS and OS compared to single\u2010modality treatment.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.27425","type":"journal-article","created":{"date-parts":[[2023,6,12]],"date-time":"2023-06-12T12:21:22Z","timestamp":1686572482000},"page":"1986-1999","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Comparing the role of different treatment modalities in locoregionally advanced olfactory neuroblastoma: The <scp>20\u2010year<\/scp> clinical experience of a <scp>single institution<\/scp>"],"prefix":"10.1002","volume":"45","author":[{"given":"Yue","family":"Chai","sequence":"first","affiliation":[{"name":"Department of Medical Oncology, National Cancer Center\/National Clinical Research Center for Cancer\/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing 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