{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,15]],"date-time":"2025-11-15T04:05:07Z","timestamp":1763179507953,"version":"3.40.5"},"reference-count":44,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2023,6,27]],"date-time":"2023-06-27T00:00:00Z","timestamp":1687824000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000048","name":"American Cancer Society","doi-asserted-by":"publisher","award":["MSRG\u201018\u2010216\u2010CPHPS"],"award-info":[{"award-number":["MSRG\u201018\u2010216\u2010CPHPS"]}],"id":[{"id":"10.13039\/100000048","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007217","name":"Health Services Research and Development","doi-asserted-by":"publisher","award":["CIN13\u2010404"],"award-info":[{"award-number":["CIN13\u2010404"]}],"id":[{"id":"10.13039\/100007217","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>We characterized prescription opioid medication use up to 2\u2009years following the head and neck cancer (HNC) diagnosis and examined associations with moderate or high daily opioid prescription dose.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Using administrative data from Veterans Health Administration, we conducted a retrospective cohort analysis of 5522 Veterans treated for cancers of the upper aerodigestive tract between 2012 and 2019. Data included cancer diagnosis and treatments, pain severity, prescription opioid characteristics, demographics, and other clinical factors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Two years post\u2010HNC<jats:italic>,<\/jats:italic> 7.8% (<jats:italic>n<\/jats:italic>\u2009=\u2009428) were receiving moderate or high\u2010dose opioid therapy. Patients with at least moderate pain (18%, <jats:italic>n<\/jats:italic>\u2009=\u2009996) had 2.48 times higher odds (95% CI\u2009=\u20091.94\u20133.09, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) to be prescribed a moderate opioid dose or higher at 2\u2009years post diagnosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Survivors of HNC with at least moderate pain were at elevated risk of continued use of moderate and high dose opioids.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.27432","type":"journal-article","created":{"date-parts":[[2023,6,27]],"date-time":"2023-06-27T09:19:42Z","timestamp":1687857582000},"page":"2058-2067","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Prevalence and correlates of high\u2010dose opioid use among survivors of head and neck cancer"],"prefix":"10.1002","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3173-6590","authenticated-orcid":false,"given":"Shannon M.","family":"Nugent","sequence":"first","affiliation":[{"name":"Center to Improve Veteran Involvement in Care VA Portland Health Care System  Portland Oregon USA"},{"name":"Department of Psychiatry Oregon Health &amp; Science University  Portland Oregon USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher G.","family":"Slatore","sequence":"additional","affiliation":[{"name":"Center to Improve Veteran Involvement in Care VA Portland Health Care System  Portland Oregon USA"},{"name":"Department of Pulmonary and Critical Care Oregon Health &amp; Science University  Portland Oregon USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kara","family":"Winchell","sequence":"additional","affiliation":[{"name":"Center to Improve Veteran Involvement in Care VA Portland Health Care System  Portland Oregon USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Handley","sequence":"additional","affiliation":[{"name":"Center to Improve Veteran Involvement in Care VA Portland Health Care System  Portland Oregon USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Clayburgh","sequence":"additional","affiliation":[{"name":"VA Portland Health Care Center Head and Neck Surgery  Portland Oregon USA"},{"name":"Department of Otolaryngology Oregon Health &amp; Science University  Portland Oregon USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ravi","family":"Chandra","sequence":"additional","affiliation":[{"name":"Department of Radiology Oregon Health &amp; Science Center  Portland Oregon USA"},{"name":"Department of Radiation Oncology Mid\u2010Atlantic Permanente Medical Group  Rockville Maryland USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth R.","family":"Hooker","sequence":"additional","affiliation":[{"name":"Center to Improve Veteran Involvement in Care VA Portland Health Care System  Portland Oregon USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara J.","family":"Knight","sequence":"additional","affiliation":[{"name":"Informatics, Decisions\u2010Enhancement and Analytic Sciences Center VA Salt Lake City Health Care System  Salt Lake City Utah USA"},{"name":"Department of Medicine University of Utah Medical Center  Salt Lake City Utah USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benjamin J.","family":"Morasco","sequence":"additional","affiliation":[{"name":"Center to Improve Veteran Involvement in Care VA Portland Health Care System  Portland Oregon USA"},{"name":"Department of Psychiatry Oregon Health &amp; Science University  Portland Oregon USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,6,27]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21254"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2006.09.2700"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/1477-7525-7-102"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2015.61.4115"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoto.2021.2625"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.27215"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599820960137"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599818778276"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.2013-0001"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/pm\/pnz242"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.26034"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2016.1464"},{"issue":"7","key":"e_1_2_10_14_1","article-title":"Opioids for cancer pain\u2014an overview of Cochrane reviews","volume":"7","author":"Wiffen PJ","year":"2017","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2018.18472"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-018-4404-x"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.7326\/M14-2559"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2021.8782"},{"issue":"10","key":"e_1_2_10_19_1","article-title":"High\u2010dose opioids for chronic non\u2010cancer pain: an overview of Cochrane reviews","volume":"10","author":"Els C","year":"2017","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000001817"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djz200"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.26591"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0000000000002496"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.25482"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoto.2017.0582"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/pon.4917"},{"key":"e_1_2_10_27_1","unstructured":"VA Corporate Data Warehouse (CDW).Accessed 7\/1\/2022.https:\/\/www.hsrd.research.va.gov\/for_researchers\/cdw.cfm"},{"key":"e_1_2_10_28_1","unstructured":"Commission on Cancer.Facility Oncology Registry Data Standards (FORDS) Manual.2016."},{"issue":"1","key":"e_1_2_10_29_1","first-page":"14","article-title":"A data quality assessment guideline for electronic health record data reuse","volume":"5","author":"Weiskopf NG","year":"2017","journal-title":"EGEMS (Wash DC)"},{"volume-title":"American College of Surgeons: Cancer Staging Manual","year":"2010","author":"Fleming I","key":"e_1_2_10_30_1"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005650-199909000-00002"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.rr6501e1"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.4065\/mcp.2009.0649"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1093\/pm\/pnab110"},{"issue":"4","key":"e_1_2_10_35_1","first-page":"176","article-title":"Cut points for mild, moderate, and severe pain among cancer and non\u2010cancer patients: a literature review","volume":"4","author":"Woo A","year":"2015","journal-title":"Ann Palliat Med"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.2011.03559.x"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004479-200407000-00011"},{"issue":"2","key":"e_1_2_10_38_1","first-page":"S1","article-title":"Clinical practice guideline: opioid prescribing for analgesia after common otolaryngology operations","volume":"164","author":"Anne S","year":"2021","journal-title":"Otolaryngol Head Neck Surg"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.27791"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599820904693"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40463-021-00508-y"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuchi.2020.11.012"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13063-016-1165-z"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpainsymman.2010.02.024"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11606-007-0321-2"}],"container-title":["Head &amp; Neck"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hed.27432","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,17]],"date-time":"2023-08-17T10:15:45Z","timestamp":1692267345000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hed.27432"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6,27]]},"references-count":44,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2023,8]]}},"alternative-id":["10.1002\/hed.27432"],"URL":"https:\/\/doi.org\/10.1002\/hed.27432","archive":["Portico"],"relation":{},"ISSN":["1043-3074","1097-0347"],"issn-type":[{"type":"print","value":"1043-3074"},{"type":"electronic","value":"1097-0347"}],"subject":[],"published":{"date-parts":[[2023,6,27]]},"assertion":[{"value":"2022-09-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-06-10","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-06-27","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}