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The aim of this study was to review the available published data on sialoblastoma in a comprehensive analysis of its clinicopathologic characteristics, treatment, and outcomes. An unrestricted electronic search was performed in the following databases: MEDLINE\/PubMed, EMBASE, Scopus, Web of science, and gray literature databases. Eligibility criteria included publications with sufficient clinical, imaging, and histopathological information to confirm the diagnosis of sialoblastoma. Data were evaluated descriptively and analytically. A total of 52 studies met the eligibility criteria. In total, 62 patients were evaluated. There was no gender predilection, with the parotid being the most affected primary site (<jats:italic>n<\/jats:italic>\u2009=\u200928; 45.2%). In the log\u2010rank test, there was a significant increase in disease\u2010associated survival in patients younger than 1\u2009year of age (82.8% vs. 44.4%; <jats:italic>p<\/jats:italic>\u2009=\u20090.003), individuals with lesions in major salivary glands (79.4% vs. 38.5%; <jats:italic>p<\/jats:italic>\u2009=\u20090.005), patients without metastases (77.8% vs. 14.3%; <jats:italic>p<\/jats:italic>\u2009=\u20090.011), encapsulated lesions (85.7% vs. 0%; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001), congenital lesions (83.3% vs. 25.0%; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001), and lesions that do not show perineural invasion (89.5% vs. 40%; <jats:italic>p<\/jats:italic>\u2009=\u20090.035). Kaplan\u2013Meier curves estimated overall survival and disease\u2010free survival at 5\u2009years of 95.5% and 68.1%, respectively. In the multivariate Cox regression model, only the presence of metastasis was identified as an independent prognostic factor (hazard ratio [HR]\u2009=\u20099.81; <jats:italic>p<\/jats:italic>\u2009=\u20090.010). Although sialoblastoma presents good prognosis, the tumor has a high recurrence rate.<\/jats:p>","DOI":"10.1002\/hed.27440","type":"journal-article","created":{"date-parts":[[2023,6,26]],"date-time":"2023-06-26T09:46:47Z","timestamp":1687772807000},"page":"2136-2148","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Clinicopathological study and survival outcomes of sialoblastoma: A systematic review"],"prefix":"10.1002","volume":"45","author":[{"given":"Vit\u00f3ria Maria Sousa","family":"Cruz","sequence":"first","affiliation":[{"name":"Oral Diagnosis Department Piracicaba Dental School, University of Campinas (UNICAMP)  Piracicaba Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Eduarda","family":"P\u00e9rez\u2010de\u2010Oliveira","sequence":"additional","affiliation":[{"name":"Oral Diagnosis Department Piracicaba Dental School, University of Campinas (UNICAMP)  Piracicaba Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8642-3834","authenticated-orcid":false,"given":"\u00c9der Gerardo","family":"dos Santos Leite","sequence":"additional","affiliation":[{"name":"Oral Diagnosis Department Piracicaba Dental School, University of Campinas (UNICAMP)  Piracicaba Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5057-4008","authenticated-orcid":false,"given":"Brendo Vinicius Rodrigues","family":"Louredo","sequence":"additional","affiliation":[{"name":"Oral Diagnosis Department Piracicaba Dental School, University of Campinas (UNICAMP)  Piracicaba Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H\u00e9len Kaline Farias","family":"Bezerra","sequence":"additional","affiliation":[{"name":"Oral Diagnosis Department Piracicaba Dental School, University of Campinas (UNICAMP)  Piracicaba Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00e1rcio Ajudarte","family":"Lopes","sequence":"additional","affiliation":[{"name":"Oral Diagnosis Department Piracicaba Dental School, University of Campinas (UNICAMP)  Piracicaba Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pablo Agustin","family":"Vargas","sequence":"additional","affiliation":[{"name":"Oral Diagnosis Department Piracicaba Dental School, University of Campinas (UNICAMP)  Piracicaba Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan Roger","family":"Santos\u2010Silva","sequence":"additional","affiliation":[{"name":"Oral Diagnosis Department Piracicaba Dental School, University of Campinas (UNICAMP)  Piracicaba Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luiz Paulo","family":"Kowalski","sequence":"additional","affiliation":[{"name":"Head and Neck Surgery Department and LIM 28 University of S\u00e3o Paulo Medical School (FMUSP)  S\u00e3o Paulo Brazil"},{"name":"Department of Head and Neck Surgery and Otorhinolaringology A.C. 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