{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T03:40:02Z","timestamp":1792381202665,"version":"4.4.0"},"reference-count":41,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2023,6,28]],"date-time":"2023-06-28T00:00:00Z","timestamp":1687910400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2023,6,28]],"date-time":"2023-06-28T00:00:00Z","timestamp":1687910400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Head &amp;amp; Neck"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The objective of this study was to assess the performance and application of a self\u2010developed deep learning (DL) algorithm for the real\u2010time localization and classification of both vocal cord carcinoma and benign vocal cord lesions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The algorithm was trained and validated upon a dataset of videos and photos collected from our own department, as well as an open\u2010access dataset named \u201cLaryngoscope8\u201d.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The algorithm correctly localizes and classifies vocal cord carcinoma on still images with a sensitivity between 71% and 78% and benign vocal cord lesions with a sensitivity between 70% and 82%. Furthermore, the best algorithm had an average frame per second rate of 63, thus making it suitable to use in an outpatient clinic setting for real\u2010time detection of laryngeal pathology.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>We have demonstrated that our developed DL algorithm is able to localize and classify benign and malignant laryngeal pathology during endoscopy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/hed.27441","type":"journal-article","created":{"date-parts":[[2023,6,28]],"date-time":"2023-06-28T05:45:00Z","timestamp":1687931100000},"page":"2217-2226","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":56,"title":["Detection of laryngeal carcinoma during endoscopy using artificial intelligence"],"prefix":"10.1002","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8437-5664","authenticated-orcid":false,"given":"David J.","family":"Wellenstein","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology and Head and Neck Surgery Radboud University Medical Center  Nijmegen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Woodburn","sequence":"additional","affiliation":[{"name":"WSK Medical B.V.  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henri A. M.","family":"Marres","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology and Head and Neck Surgery Radboud University Medical Center  Nijmegen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guido B.","family":"van den Broek","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology and Head and Neck Surgery Radboud University Medical Center  Nijmegen The Netherlands"},{"name":"Department of Information Management Radboud University Medical Center  Nijmegen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,6,28]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"9","volume-title":"On the Surgical Treatment of Polypi of the Larynx, and Oedema of the Glottis","author":"Green H","year":"1852"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1098\/rspl.1854.0094"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1121\/1.1910752"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1067\/mhn.2001.117873"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348940311201109"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.24819"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvoice.2017.07.018"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-021-06673-0"},{"key":"e_1_2_7_10_1","first-page":"432","volume-title":"Machine Learning","author":"Mitchell TM","year":"1997"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02478259"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-60327-101-1_2"},{"key":"e_1_2_7_13_1","article-title":"OverFeat: integrated recognition, localisation, and detection using convolutional networks","author":"Sermanet P","year":"2014","journal-title":"arXiv"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1080\/00016480310000412"},{"key":"e_1_2_7_15_1","first-page":"69","article-title":"Intelligent vocal cord image analysis for categorizing laryngeal diseases","volume":"3533","author":"Verikas A","year":"2005","journal-title":"Lect Notes Artif Int"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.artmed.2004.11.001"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.24151"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.compbiomed.2015.02.001"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1109\/JBHI.2014.2374975"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1117\/1.JMI.4.3.034502"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11548-018-01910-0"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11517-019-02051-5"},{"key":"e_1_2_7_23_1","doi-asserted-by":"crossref","unstructured":"CenQ PanZP LiY DingHJ.Laryngeal tumor detection in endoscopic images based on convolutional neural network. Paper presented at Proceedings of 2019 IEEE 2nd International Conference on Electronic Information and Communication Technology (ICEICT 2019) pp. 604\u2010608.2019.","DOI":"10.1109\/ICEICT.2019.8846399"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2019.08.075"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.3390\/s20144018"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.28539"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvoice.2020.08.003"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.26313"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.29595"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.patrec.2021.06.034"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.21037\/atm-21-6458"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1177\/0003489420950364"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.29960"},{"key":"e_1_2_7_34_1","doi-asserted-by":"crossref","unstructured":"RedmonJ DivvalaS GirshickR FarhadiA.You only look once: unified real\u2010time object detection. Paper presented at Proceedings under Conference on Computer Vision and Pattern Recognition (CVPR) pp. 779\u2010788.2016.","DOI":"10.1109\/CVPR.2016.91"},{"key":"e_1_2_7_35_1","unstructured":"YOLOv5 GitHub repository.2022.https:\/\/github.com\/ultralytics\/yolov5"},{"key":"e_1_2_7_36_1","article-title":"Microsoft COCO: common objects in context","author":"Lin T\u2010Y","year":"2015","journal-title":"ArXiv"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11263-009-0275-4"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.33037"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1177\/0003489418793987"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvoice.2020.04.015"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-017-4647-z"},{"key":"e_1_2_7_42_1","unstructured":"https:\/\/mydre.org\/."}],"container-title":["Head &amp; Neck"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hed.27441","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/hed.27441","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hed.27441","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T02:58:06Z","timestamp":1792378686000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hed.27441"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6,28]]},"references-count":41,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2023,9]]}},"alternative-id":["10.1002\/hed.27441"],"URL":"https:\/\/doi.org\/10.1002\/hed.27441","archive":["Portico"],"relation":{},"ISSN":["1043-3074","1097-0347"],"issn-type":[{"value":"1043-3074","type":"print"},{"value":"1097-0347","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,6,28]]},"assertion":[{"value":"2022-10-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-06-18","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-06-28","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}