{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T03:40:08Z","timestamp":1792381208931,"version":"4.4.0"},"reference-count":34,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2023,7,4]],"date-time":"2023-07-04T00:00:00Z","timestamp":1688428800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2023,7,4]],"date-time":"2023-07-04T00:00:00Z","timestamp":1688428800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Head &amp;amp; Neck"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>To determine the safety of Botox and its potential effect on alleviating radiation therapy (RT)\u2010induced sialadenitis in head and neck cancer patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Twenty patients with stage III\/IV head and neck cancer were randomized to receive Botox or saline injections into both submandibular glands (SMG). There were three visits: one before RT (V1); 1 week after RT (V2); and 6\u2009weeks after RT (V3), each of which included saliva collection, a 24\u2010h dietary recall, and a quality\u2010of\u2010life survey.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>No adverse events were observed. While the control group was much older, the Botox group more commonly underwent induction chemotherapy compared with controls. From V1 to V2, salivary flow decreased in both groups, but only in the control group from V1 to V3. CXCL\u20101 (GRO), a neutrophil chemoattractant, was lower in the Botox group compared with the control group at V3.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Botox can be safely administered to the salivary glands prior to external beam radiation without observed complications or side\u2010effects. After an initial reduction in salivary flow following RT, the Botox group showed lack of further flow reduction compared with controls. The inflammatory marker CXCL 1, which was reduced in the in Botox group at V3, may be a candidate for further studies of radiation\u2010induced sialadenitis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/hed.27449","type":"journal-article","created":{"date-parts":[[2023,7,5]],"date-time":"2023-07-05T02:47:44Z","timestamp":1688525264000},"page":"2198-2206","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Botox for the prevention of radiation\u2010induced Sialadenitis and xerostomia in head and neck cancer patients: A pilot study"],"prefix":"10.1002","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1087-2799","authenticated-orcid":false,"given":"Chad Alexander","family":"Nieri","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2014 Head and Neck Surgery University of Tennessee Health Science Center  Memphis Tennessee USA"},{"name":"Department of Otolaryngology\u2014Head and Neck Surgery Washington University School of Medicine  St. Louis Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ezer Haim","family":"Benaim","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2014 Head and Neck Surgery University of Tennessee Health Science Center  Memphis Tennessee USA"},{"name":"Department of Otolaryngology\u2014Head and Neck Surgery University of North Carolina  Chapel Hill North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanhui H.","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Bioscience Research, College of Dentistry University of Tennessee Health Science Center  Memphis Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franklin","family":"Garcia\u2010Godoy","sequence":"additional","affiliation":[{"name":"Department of Bioscience Research, College of Dentistry University of Tennessee Health Science Center  Memphis Tennessee USA"},{"name":"The Forsyth Institute  Cambridge Massachusetts USA"},{"name":"Department of Surgery, Herbert Wertheim, College of Medicine Florida International University  Miami Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J.","family":"Herr","sequence":"additional","affiliation":[{"name":"Department of Cell, Developmental, and Integrative Biology University of Alabama at Birmingham Heersink School of Medicine  Birmingham Alabama USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiqiang","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, College of Medicine University of Tennessee Health Science Center  Memphis Tennessee USA"},{"name":"Department of Physiology, College of Medicine University of Tennessee Health Science Center  Memphis Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Schwartz","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology University of Tennessee Health Science Center  Memphis Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kimberly K.","family":"Coca","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Head and Neck Surgery University of South Florida  Tampa Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0325-5637","authenticated-orcid":false,"given":"John P.","family":"Gleysteen","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2014 Head and Neck Surgery University of Tennessee Health Science Center  Memphis Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marion Boyd","family":"Gillespie","sequence":"additional","affiliation":[{"name":"Department of 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