{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,4]],"date-time":"2025-06-04T10:08:12Z","timestamp":1749031692890,"version":"3.40.5"},"reference-count":16,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2023,7,13]],"date-time":"2023-07-13T00:00:00Z","timestamp":1689206400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>To evaluate the role of definitive weekly hypofractionated radiotherapy (RT) for the treatment of surgery\u2010ineligible elderly patients with cutaneous squamous cell carcinoma of the head and neck region (cHNSCC).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Eligible elderly patients (aged \u226575\u2009years) with cHNSCC were included. Patients received definitive weekly hypofractionated RT, using megavoltage electrons, to a total dose of 56\u201364\u2009Gy (8\u2009Gy per fraction). Primary endpoint was objective response rate (ORR), defined as the percentage of patients with a complete (CR) or partial response (PR). Secondary endpoints included duration of response (DOR), progression\u2010free survival (PFS), overall survival (OS), pain response, tolerability, and safety.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 19 patients with 27 lesions were included and treated with definitive weekly hypofractionated RT. All patients received the prescribed total dose. ORR was 92.6%, including 70.4% of lesions with a CR and 22.2% with a PR. Median DOR was 12\u2009months. No severe toxicity occurred.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our study confirmed the satisfying efficacy and acceptable toxicity of definitive weekly hypofractionated RT for cHNSCC in elderly patients. Our results establish weekly hypofractionated scheduleas a promising treatment option for elderly patients with cHNSCC.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.27454","type":"journal-article","created":{"date-parts":[[2023,7,13]],"date-time":"2023-07-13T10:10:46Z","timestamp":1689243046000},"page":"2363-2368","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Surgery\u2010ineligible elderly patients with cutaneous squamous cell carcinoma of the head and neck region gain clinical benefit from definitive weekly hypofractionated radiotherapy"],"prefix":"10.1002","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5119-8358","authenticated-orcid":false,"given":"Francesca","family":"De Felice","sequence":"first","affiliation":[{"name":"Radiation Oncology, Policlinico Umberto I, Department of Radiological, Oncological and Pathological Sciences \u201cSapienza\u201d University of Rome  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Serpone","sequence":"additional","affiliation":[{"name":"Radiation Oncology, Policlinico Umberto I, Department of Radiological, Oncological and Pathological Sciences \u201cSapienza\u201d University of Rome  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlo Guglielmo","family":"Cattaneo","sequence":"additional","affiliation":[{"name":"Radiation Oncology, Policlinico Umberto I, Department of Radiological, Oncological and Pathological Sciences \u201cSapienza\u201d University of Rome  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Federico","family":"Di Giammarco","sequence":"additional","affiliation":[{"name":"Radiation Oncology, Policlinico Umberto I, Department of Radiological, Oncological and Pathological Sciences \u201cSapienza\u201d University of Rome  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alberto","family":"Fallico","sequence":"additional","affiliation":[{"name":"Radiation Oncology, Policlinico Umberto I, Department of Radiological, Oncological and Pathological Sciences \u201cSapienza\u201d University of Rome  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessia","family":"Delle Donne","sequence":"additional","affiliation":[{"name":"Radiation Oncology, Policlinico Umberto I, Department of Radiological, Oncological and Pathological Sciences \u201cSapienza\u201d University of Rome  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maura","family":"Lanzilao","sequence":"additional","affiliation":[{"name":"Radiation Oncology, Policlinico Umberto I, Department of Radiological, Oncological and Pathological Sciences \u201cSapienza\u201d University of Rome  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisa","family":"Vitti","sequence":"additional","affiliation":[{"name":"Radiation Oncology, Policlinico Umberto I, Department of Radiological, Oncological and Pathological Sciences \u201cSapienza\u201d University of Rome  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco","family":"Marampon","sequence":"additional","affiliation":[{"name":"Radiation Oncology, Policlinico Umberto I, Department of Radiological, Oncological and Pathological Sciences \u201cSapienza\u201d University of Rome  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniela","family":"Musio","sequence":"additional","affiliation":[{"name":"Radiation Oncology, Policlinico Umberto I, Department of Radiological, Oncological and Pathological Sciences \u201cSapienza\u201d University of Rome  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vincenzo","family":"Tombolini","sequence":"additional","affiliation":[{"name":"Radiation Oncology, Policlinico Umberto I, Department of Radiological, Oncological and Pathological Sciences \u201cSapienza\u201d University of Rome  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppe","family":"Minniti","sequence":"additional","affiliation":[{"name":"Radiation Oncology, Policlinico Umberto I, Department of Radiological, Oncological and Pathological Sciences \u201cSapienza\u201d University of Rome  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,7,13]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21763"},{"key":"e_1_2_8_3_1","unstructured":"National Comprehensive Cancer Network Clinical Practice Guidelines in Oncology (NCCN Guidelines\u00ae) Squamous Cell Skin Cancer version 1.2023.http:\/\/www.nccn.org\/. 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