{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T03:40:01Z","timestamp":1792381201003,"version":"4.4.0"},"reference-count":55,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2023,7,14]],"date-time":"2023-07-14T00:00:00Z","timestamp":1689292800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2023,7,14]],"date-time":"2023-07-14T00:00:00Z","timestamp":1689292800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100004410","name":"Scientific and Technological Research Council of Turkey","doi-asserted-by":"publisher","award":["118Z767"],"award-info":[{"award-number":["118Z767"]}],"id":[{"id":"10.13039\/501100004410","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Head &amp;amp; Neck"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Oral squamous cell carcinoma (OSCC) is characterized by enhanced angiogenesis resulting in poor prognosis despite improvements in diagnostic\/therapeutic techniques. Here, we aimed at investigating potential roles of miR\u20101825 enclosed in OSCC\u2010derived exosomes on angiogenesis under hypoxic conditions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Effects of miR\u20101825 mimic\/inhibitor as well as hypoxia\u2010induced tumor derived exosomes on human umbilical vein endothelial cells (HUVECs) were evaluated using cell viability, migration\/invasion, tube formation, and spheroid\u2010based 3D angiogenesis assays.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Hypoxic conditions caused significant increase in miR\u20101825 levels in OSCC cells and hiTDEs. miR\u20101825 alone and within hiTDEs promoted endothelial cell viability, migration, invasion, and angiogenic potential, which is reversed via inhibition of miR\u20101825 expression. miR\u20101825 within hiTDEs altered the angiogenesis potential of HUVEC cells via deregulation of TSC2\/mTOR axis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>We showed that hypoxia led to OSCC\u2010derived exosome mediated transfer of miR\u20101825 to HUVECs and enhanced angiogenesis in OSCC in vitro.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/hed.27460","type":"journal-article","created":{"date-parts":[[2023,7,14]],"date-time":"2023-07-14T06:30:02Z","timestamp":1689316202000},"page":"2259-2273","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Hypoxia\u2010induced tumor exosomes promote angiogenesis through\n                    <scp>miR<\/scp>\n                    \u20101825\/\n                    <scp>TSC2<\/scp>\n                    \/\n                    <scp>mTOR<\/scp>\n                    axis in oral squamous cell carcinoma"],"prefix":"10.1002","volume":"45","author":[{"given":"Ozel","family":"Capik","sequence":"first","affiliation":[{"name":"Department of Molecular Biology and Genetics Erzurum Technical University  Erzurum Turkey"},{"name":"Molecular Cancer Biology Laboratory, High Technology Application and Research Center Erzurum Technical University  Erzurum Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rasim","family":"Gumus","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology and Genetics Erzurum Technical University  Erzurum Turkey"},{"name":"Molecular Cancer Biology Laboratory, High Technology Application and Research Center Erzurum Technical University  Erzurum Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0379-2088","authenticated-orcid":false,"given":"Omer 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