{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T19:22:28Z","timestamp":1790018548434,"version":"4.0.1"},"reference-count":45,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2023,9,28]],"date-time":"2023-09-28T00:00:00Z","timestamp":1695859200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>This systematic review study aims to provide comprehensive data on different radiobiological models, parameters, and endpoints used for calculating the normal tissue complication probability (NTCP) based on clinical data from head and neck cancer patients treated with conformal radiotherapy. A systematic literature search was carried out according to the PRISMA guideline for the identification of relevant publications in six electronic databases of Embase, PubMed, Scopus, and Google Scholar to July 2022 using specific keywords in the paper's title and abstract. The initial search resulted in 1368 articles for all organs for the review article about the NTCP parameters. One hundred and seventy\u2010eight articles were accepted for all organs with complete parameters for the mentioned models and finally, 20 head and neck cancer articles were accepted for review. Analysis of the studies shows that the Lyman\u2010Kutcher\u2010Burman (LKB) model properly links the NTCP curve parameters to the postradiotherapy endpoints. In the LKB model for esophagus, the minimum, and maximum corresponding parameters were reported as TD<jats:sub>50<\/jats:sub>\u2009=\u20092.61\u2009Gy with grade \u22653 radiation\u2010induced esophagitis endpoints as the minimum TD<jats:sub>50<\/jats:sub> and TD<jats:sub>50<\/jats:sub>\u2009=\u200968\u2009Gy as the maximum ones. <jats:italic>n<\/jats:italic><jats:sub>min<\/jats:sub>\u2009=\u20090.06, <jats:italic>n<\/jats:italic><jats:sub>max<\/jats:sub>\u2009=\u20091.04, <jats:italic>m<\/jats:italic><jats:sub>min<\/jats:sub>\u2009=\u20090.1, and <jats:italic>m<\/jats:italic><jats:sub>max<\/jats:sub>\u2009=\u20090.65, respectively. Unfortunately, there was not a wide range of published articles on other organs at risk like ear or cauda equina except Burman et al. (Fitting of normal tissue tolerance data to an analytic function. <jats:italic>Int J Radiat Oncol Biol Phys Ther<\/jats:italic>. 1991;21:123\u2013135). Findings suggest that the validation of different radiobiological models and their corresponding parameters need to be investigated in vivo and in vitro for developing a more accurate NTCP model to be used for radiotherapy treatment planning optimization.<\/jats:p>","DOI":"10.1002\/hed.27469","type":"journal-article","created":{"date-parts":[[2023,9,28]],"date-time":"2023-09-28T10:28:13Z","timestamp":1695896893000},"page":"3146-3156","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["A systematic review of the normal tissue complication probability models and parameters: Head and neck cancers treated with conformal radiotherapy"],"prefix":"10.1002","volume":"45","author":[{"given":"Sareh","family":"Tajiki","sequence":"first","affiliation":[{"name":"Radiotherapy Oncology Research Centre, Cancer Institute Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Musa","family":"Joya","sequence":"additional","affiliation":[{"name":"Department of Medical Physics and Biomedical Engineering Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vahideh","family":"Gharekhani","sequence":"additional","affiliation":[{"name":"Department of Radiobiology, Faculty of Paramedical Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dylan","family":"Richeson","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Virginia Commonwealth University  Richmond Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3014-1934","authenticated-orcid":false,"given":"Somayeh","family":"Gholami","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology University of Arkansas for Medical Sciences  Little Rock Arkansas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,9,28]]},"reference":[{"issue":"2","key":"e_1_2_7_2_1","first-page":"99","article-title":"TCP and NTCP: a basic introduction","volume":"30","author":"Baumann M","year":"2005","journal-title":"Rays."},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1120\/jacmp.v5i1.1970"},{"key":"e_1_2_7_4_1","article-title":"Parameters of the Lyman model for calculation of normal tissue complication probability: a systematic literature review","author":"Dennst\u00e4dt F","year":"2022","journal-title":"International Journal of Radiation Oncology* Biology*Physics."},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1120\/jacmp.v14i5.4316"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1118\/1.596781"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1080\/09553009214552071"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0167-8140(91)90093-V"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1080\/09553000110047555"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/0360-3016(88)90098-3"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/0167-8140(93)90264-9"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1118\/1.597056"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/0360-3016(94)00471-4"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/0360-3016(91)90171-Y"},{"key":"e_1_2_7_15_1","doi-asserted-by":"crossref","unstructured":"RoswitB.Complications of radiation therapy: the alimentary tract. 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