{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,18]],"date-time":"2026-01-18T11:58:49Z","timestamp":1768737529862,"version":"3.49.0"},"reference-count":27,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2023,9,12]],"date-time":"2023-09-12T00:00:00Z","timestamp":1694476800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The prognostic impact of depth of invasion (DOI) in American Joint Committee on Cancer 8th edition TNM staging for oral cavity squamous cell carcinoma (OCSCCa) across oral cavity subsites is unknown.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Overall survival of patients with pT1\u20104a OCSCCa in the National Cancer Database (2010\u20132017), stratified by tumor size and DOI across eight oral cavity subsites, was evaluated using multivariable\u2010adjusted Cox proportional hazards modeling.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>When stratified by tumor size \u22642\u2009cm and\u2009&gt;2\u2009cm, DOI\u2009&gt;5\u2009mm and DOI\u2009&gt;10\u2009mm were only associated with worse overall survival, respectively, for tumors of the oral tongue (Tumor size \u22642\u2009cm, DOI\u2009&gt;5\u2009mm v DOI \u22645\u2009mm: HR: 1.31, 95% CI: 1.12\u20131.53, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001; Tumor size &gt;2\u2009cm, DOI\u2009&gt;10\u2009mm v DOI\u2009\u226410\u2009mm: HR: 1.15, 95% CI: 1.01\u20131.30, <jats:italic>p<\/jats:italic>\u2009=\u20090.03). DOI\u2009&gt;5\u2009mm and DOI\u2009&gt;10\u2009mm was not prognostic for any other tumor location.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>These findings suggest that the current staging schema for DOI in OCSCCa may not be prognostic across all oral cavity subsites.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.27497","type":"journal-article","created":{"date-parts":[[2023,9,12]],"date-time":"2023-09-12T14:39:01Z","timestamp":1694529541000},"page":"2780-2788","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Evaluating depth of invasion across oral cavity subsites as part of the <scp>AJCC<\/scp> 8th edition T staging criteria for oral cavity squamous cell carcinoma"],"prefix":"10.1002","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5574-8620","authenticated-orcid":false,"given":"Shivee","family":"Gilja","sequence":"first","affiliation":[{"name":"Department of Otolaryngology \u2010 Head and Neck Surgery Icahn School of Medicine at Mount Sinai  New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joshua","family":"Barlow","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology \u2010 Head and Neck Surgery Icahn School of Medicine at Mount Sinai  New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arvind","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology \u2010 Head and Neck Surgery Icahn School of Medicine at Mount Sinai  New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael H.","family":"Berger","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology \u2010 Head and Neck Surgery Icahn School of Medicine at Mount Sinai  New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohemmed N.","family":"Khan","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology \u2010 Head and Neck Surgery Icahn School of Medicine at Mount Sinai  New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diana N.","family":"Kirke","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology \u2010 Head and Neck Surgery Icahn School of Medicine at Mount Sinai  New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Scott A.","family":"Roof","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology \u2010 Head and Neck Surgery Icahn School of Medicine at Mount Sinai  New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,9,12]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-40618-3"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-0-387-88441-7"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21389"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2017.05.020"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjoms.2017.11.009"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2018.04.018"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/his.13886"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1054\/jcms.1999.0070"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.25553"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.25785"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0002\u20109610(00)00433\u20105"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoto.2014.1548"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2018.12.017"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1177\/01945998221098011"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1177\/01945998221101191"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.27205"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejso.2021.03.243"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.3892\/ol.2023.13661"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.20275"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1186\/1748\u2010717x\u20105\u201043"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.23380"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1159\/000343796"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.24724"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/odi.13194"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.4103\/jcrt.JCRT_783_20"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10147\u2010018\u20101276\u20105"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.1144"}],"container-title":["Head 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