{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T02:10:33Z","timestamp":1778292633003,"version":"3.51.4"},"reference-count":26,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,11,5]],"date-time":"2023-11-05T00:00:00Z","timestamp":1699142400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To demonstrate adequacy of radiation therapy alone to the neck in patients with maxillary sinus squamous cell carcinoma (MS\u2010SCC) without clinical evidence of regional metastasis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Retrospective review between 2000 and 2018 from a single high\u2010volume tertiary academic head and neck cancer center of all patients with MS\u2010SCC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 55 patients were treated for MS\u2010SCC at our center. A clinically uninvolved neck on presentation was found in 46 patients (83.6%) in the initial dataset. Of the 39 patients with radiologic N0 disease who were treated with primary surgical resection, 15.4% (6 patients) did not undergo any treatment of the neck, 2.6% (1 patient) underwent a neck dissection only, 69.2% (27 patients) received RT only, and 12.8% (5 patients) were treated with both a neck dissection followed by RT. Median follow\u2010up was 26\u2009months (mean 48\u2009months, interquartile range 9\u201376\u2009months). Five\u2010year overall survival of all patients with N0 necks treated with upfront surgical resection was 46.5% (95% CI, 32.3%\u201366.9%). No patients with N0 necks had isolated regional recurrence regardless of neck management.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Regional recurrence is rare for patients with radiologic N0 MS\u2010SCC. Single\u2010modality elective neck radiation provides excellent regional disease control in these patients.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.27512","type":"journal-article","created":{"date-parts":[[2023,11,6]],"date-time":"2023-11-06T06:17:17Z","timestamp":1699251437000},"page":"171-176","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Elective management of the <scp>N0<\/scp> neck in maxillary sinus squamous cell carcinoma"],"prefix":"10.1002","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9300-4390","authenticated-orcid":false,"given":"Evan J.","family":"Patel","sequence":"first","affiliation":[{"name":"Department of Otolaryngology \u2013 Head &amp; Neck Surgery University of California San Francisco  San Francisco California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Madeleine P.","family":"Strohl","sequence":"additional","affiliation":[{"name":"Ear, Nose and Throat University of Louisville Health  Louisville Kentucky USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sue S.","family":"Yom","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology University of California San Francisco  San Francisco California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8121-3726","authenticated-orcid":false,"given":"Ivan","family":"El\u2010Sayed","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology \u2013 Head &amp; Neck Surgery University of California San Francisco  San Francisco California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,11,5]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2012.04.005"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.21830"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.3109\/02841869709100727"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19930501)71:9<2715::AID-CNCR2820710905>3.0.CO;2-0"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/moo.0000000000000138"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.3857\/roj.2018.00416"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2012.10.002"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/archoto.2007.30"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0360\u20103016(99)00453\u20108"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0360\u20103016(97)00293\u20109"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/scs.0b013e3181d878d1"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0385\u20108146(01)00080\u20103"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.5125\/jkaoms.2017.43.3.166"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjoms.2012.04.004"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.128.1.58"},{"issue":"3","key":"e_1_2_7_17_1","first-page":"113","article-title":"Elective neck dissection in oral carcinoma: a critical review of the evidence","volume":"27","author":"Kowalski LP","year":"2007","journal-title":"Acta Otorhinolaryngol Ital"},{"key":"e_1_2_7_18_1","unstructured":"National Comprehensive Cancer Network.NCCN clinical practice guidelines for oncology: head and neck cancers. 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