{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T06:41:14Z","timestamp":1777704074254,"version":"3.51.4"},"reference-count":37,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2023,9,8]],"date-time":"2023-09-08T00:00:00Z","timestamp":1694131200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>There is a paucity of data concerning molecular heterogeneity among glottic squamous cell carcinoma, and the clinical implications thereof.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Data corresponding to glottic squamous cell carcinoma were derived from The Cancer Genome Atlas. The Onco\u2010GPS computational methodology was levied to derive four patterns of transcriptional activity and three functional subtypes of glottic cancer.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Thirty glottic cancer samples stratified to three distinct oncogenic states (S0\u2013S2) based on a Onco\u2010GPS model containing four transcriptional components (F0\u2010F3). Membership in S2 and association with transcriptional component F0 conveyed an invasive phenotype, with transcriptional activity strongly reflecting EMT programming (including TGF\u2010B and NF\u2010KB signaling). S2 membership also correlated with inferior disease\u2010specific survival (HR 9.027, 95% CI 1.021\u201379.767), and higher incidences of extracapsular spread and perineural invasion.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>We present a functional taxonomy of glottic cancer, with subtypes demonstrating differential upregulation of canonical oncogenic networks and survival implications.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.27514","type":"journal-article","created":{"date-parts":[[2023,9,8]],"date-time":"2023-09-08T14:00:02Z","timestamp":1694181602000},"page":"2851-2861","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Transcriptional subtypes of glottic cancer characterized by differential activation of canonical oncogenic programming"],"prefix":"10.1002","volume":"45","author":[{"given":"Bharat A.","family":"Panuganti","sequence":"first","affiliation":[{"name":"Department of Otolaryngology \u2013 Head and Neck Surgery The University of Alabama at Birmingham  Birmingham Alabama USA"},{"name":"Birmingham Veteran Affairs Health Care System  Birmingham Alabama USA"},{"name":"The University of Alabama at Birmingham School of Medicine  Birmingham Alabama USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christine","family":"Carico","sequence":"additional","affiliation":[{"name":"The University of Alabama at Birmingham School of Medicine  Birmingham Alabama USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harishanker","family":"Jeyarajan","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology \u2013 Head and Neck Surgery The University of Alabama at Birmingham  Birmingham Alabama USA"},{"name":"The University of Alabama at Birmingham School of Medicine  Birmingham Alabama USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mitchell","family":"Flagg","sequence":"additional","affiliation":[{"name":"University of California\u2010San Diego School of Medicine  San Diego California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pablo","family":"Tamayo","sequence":"additional","affiliation":[{"name":"University of California\u2010San Diego School of Medicine  San Diego California USA"},{"name":"Moores Cancer Center, Center for Novel Therapeutics and Division of Genomics and Precision Medicine University of California\u2010San Diego School of Medicine  San Diego California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,9,8]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/lio2.353"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0194\u20105998(99)70052\u20105"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdr576"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0070429"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2011.03.013"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010018\u201024780\u20107"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/5980567"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjorl.2020.06.013"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078\u20100432.CCR\u201010\u20100799"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.133.12.1270"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0060157"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoto.2022.3636"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13010105"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.prp.2022.154085"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2021.683915"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature14129"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cels.2017.08.002"},{"key":"e_1_2_8_19_1","unstructured":"Broad Insititue TCGA Genome Data Analysis Center.Firehose VERSION stddata_2016_01_28. 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