{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T07:13:39Z","timestamp":1784099619726,"version":"3.55.0"},"reference-count":36,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2023,9,20]],"date-time":"2023-09-20T00:00:00Z","timestamp":1695168000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>A multicentric study was conducted on technical reproducibility of compartmental tongue surgery (CTS) in advanced tongue cancers (OTSCC) and comparison to standard wide margin surgery (SWMS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We studied 551 patients with OTSCC treated by CTS and 50 by SWMS. Oncological outcomes were analyzed. A propensity score was performed to compare survival endpoints for the two cohorts.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In the CTS group, survival and prognosis were significantly associated with positive lymph\u2010nodes, extranodal extension, depth of invasion and involvement of the soft tissue connecting the tongue primary tumor to neck lymph nodes (T\u2010N tract), independently from the center performing the surgery. SWMS versus CTS showed a HR Cause\u2010Specific Survival (CSS) of 3.24 (95% CI: 1.71\u20136.11; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001); HR Loco\u2010Regional Recurrence Free Survival (LRRFS) of 2.54 (95% CI: 1.47\u20134.40; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001); HR Overall Survival (OS) of 0.11 (95% CI: 0.01\u20130.77; <jats:italic>p<\/jats:italic>\u2009=\u20090.03).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Performing the CTS could provide better CSS and LRRFS than SWMS regardless of the center performing the surgery, in advanced OTSSC.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.27517","type":"journal-article","created":{"date-parts":[[2023,9,20]],"date-time":"2023-09-20T07:49:25Z","timestamp":1695196165000},"page":"2862-2873","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Compartmental tongue surgery for intermediate\u2010advanced squamous cell carcinoma: A multicentric study"],"prefix":"10.1002","volume":"45","author":[{"given":"Luca","family":"Calabrese","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery Hospital of Bolzano (SABES\u2010ASDAA), Teaching Hospital of the Paracelsus Medical Private University (PMU)  Bolzano Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7879-4846","authenticated-orcid":false,"given":"Marta","family":"Tagliabue","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology and Head and Neck Surgery IEO, European Institute of Oncology IRCCS  Milan Italy"},{"name":"Department of Biomedical Sciences University of Sassari  Sassari Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"Grammatica","sequence":"additional","affiliation":[{"name":"Unit of Otorhinolaryngology \u2013 Head and Neck Surgery, ASST Spedali Civili of Brescia, Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health University of Brescia, School of Medicine  Brescia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4959-587X","authenticated-orcid":false,"given":"Rita","family":"De Berardinis","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology and Head and Neck Surgery IEO, European Institute of Oncology IRCCS  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federica","family":"Corso","sequence":"additional","affiliation":[{"name":"Department of Mathematics (DMAT) Politecnico di Milano  Milan Italy"},{"name":"Centre for Health Data Science (CHDS), Human Techonopole  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Gazzini","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery Hospital of Bolzano (SABES\u2010ASDAA), Teaching Hospital of the Paracelsus Medical Private University (PMU)  Bolzano Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monir","family":"Abousiam","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery Hospital of Bolzano (SABES\u2010ASDAA), Teaching Hospital of the Paracelsus Medical Private University (PMU)  Bolzano Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrico","family":"Fazio","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery Hospital of Bolzano (SABES\u2010ASDAA), Teaching Hospital of the Paracelsus Medical Private University (PMU)  Bolzano Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7023-6746","authenticated-orcid":false,"given":"Davide","family":"Mattavelli","sequence":"additional","affiliation":[{"name":"Unit of Otorhinolaryngology \u2013 Head and Neck Surgery, ASST Spedali Civili of Brescia, Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health University of Brescia, School of Medicine  Brescia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Walter","family":"Fontanella","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Maxillofacial, and Thyroid Surgery Fondazione IRCCS National Cancer Institute of Milan  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorenzo","family":"Giannini","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Maxillofacial, and Thyroid Surgery Fondazione IRCCS National Cancer Institute of Milan  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorenzo","family":"Bresciani","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Maxillofacial, and Thyroid Surgery Fondazione IRCCS National Cancer Institute of 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