{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T08:19:44Z","timestamp":1768810784252,"version":"3.49.0"},"reference-count":45,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2023,9,22]],"date-time":"2023-09-22T00:00:00Z","timestamp":1695340800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>This study aimed to investigate prevalences of head and neck cancers in patients with and those without Sj\u00f6gren's syndrome using a population\u2010based dataset.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We retrieved sampled patients from Taiwan's Longitudinal Health Insurance Database. This study included 38\u2009930 patients with Sj\u00f6gren's syndrome and 155\u2009720 propensity\u2010score matched comparison patients without Sj\u00f6gren's syndrome.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Chi\u2010squared tests revealed that there was a statistically significant difference in the prevalences of head and neck cancers between patients with Sj\u00f6gren's syndrome and comparison patients (1.77% vs. 1.22%, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). The odds ratio for head and neck cancers for patients with Sj\u00f6gren's syndrome relative to the comparison group was 1.452 (95% CI\u2009=\u20091.325\u20131.592).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our study demonstrated that patients with Sj\u00f6gren's syndrome face increased odds of head and neck cancers, encompassing several sites including the oral cavity, oropharynx, nasopharynx, and thyroid.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.27518","type":"journal-article","created":{"date-parts":[[2023,9,22]],"date-time":"2023-09-22T12:38:30Z","timestamp":1695386310000},"page":"2874-2881","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Increased prevalences of head and neck cancers in patients with Sj\u00f6gren's syndrome"],"prefix":"10.1002","volume":"45","author":[{"given":"Tzong\u2010Hann","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology Taipei City Hospital  Taipei Taiwan"},{"name":"Department of Speech, Language and Audiology National Taipei University of Nursing and Health  Taipei Taiwan"},{"name":"Department of Otorhinolaryngology National Yang Ming Chiao Tung University, School of Medicine  Taipei Taiwan"},{"name":"Center of General Education University of Taipei  Taipei Taiwan"},{"name":"Research Center of Sleep Medicine, College of Medicine Taipei Medical University  Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yen\u2010Fu","family":"Cheng","sequence":"additional","affiliation":[{"name":"Research Center of Sleep Medicine, College of Medicine Taipei Medical University  Taipei Taiwan"},{"name":"Department of Medical Research Taipei Veterans General Hospital  Taipei Taiwan"},{"name":"Department of Otolaryngology\u2010Head and Neck Surgery Taipei Veterans General Hospital  Taipei Taiwan"},{"name":"Department of Otolaryngology\u2010Head and Neck Surgery, School of Medicine National Yang Ming Chiao Tung University  Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chin\u2010Shyan","family":"Chen","sequence":"additional","affiliation":[{"name":"Research Center of Sleep Medicine, College of Medicine Taipei Medical University  Taipei Taiwan"},{"name":"Department of Economics National Taipei University  New Taipei City Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4661-959X","authenticated-orcid":false,"given":"Herng\u2010Ching","family":"Lin","sequence":"additional","affiliation":[{"name":"School of Health Care Administration, College of Management Taipei Medical University  Taipei Taiwan"},{"name":"Research Center of Sleep Medicine Taipei Medical University Hospital  Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,9,22]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10238-021-00728-6"},{"key":"e_1_2_8_3_1","unstructured":"The Autoimmune Association.What is Sj\u00f6gren's Disease.2022. 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