{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,18]],"date-time":"2026-01-18T11:52:05Z","timestamp":1768737125978,"version":"3.49.0"},"reference-count":35,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2023,9,22]],"date-time":"2023-09-22T00:00:00Z","timestamp":1695340800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>We aimed to describe the association between trigeminal nerve (TN) dose and toxicity and determine a threshold value that leads to TN toxicity in patients with parotid tumors treated with adjuvant conventional fractionated radiation therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and Materials<\/jats:title><jats:p>Eighteen patients who underwent adjuvant radiotherapy (RT) between 2013 and 2018 were included in this retrospective study. TN and its branches were outlined subsequently on the planning CT scans. The doses received by TN were obtained based on the dose\u2013volume histogram. The dose and toxicity relationship was investigated over the total prescribed dose. RT\u2010related toxicity was graded according to Common Terminology Criteria for Adverse Events V4.0 (CTCAEv4.0).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The median follow\u2010up was 29.5\u2009months. After RT, 61% of patients had Grade I\u2013II late TN toxicity divided into Grade I in 4 (22%) and Grade II in 7 (39%) patients. TN injury symptoms were as follows: loss of sensation in the chin area in 3, difficulty in jaw movements in 3, and paresthesia in 5 patients. The total RT dose (<jats:italic>p<\/jats:italic>\u2009=\u20090.001), Dmax (<jats:italic>p<\/jats:italic>\u2009=\u20090.001), PTV\u2010TN Dmax (<jats:italic>p<\/jats:italic>\u2009=\u20090.001), D1cc (<jats:italic>p<\/jats:italic>\u2009=\u20090.004), D0.5cc (<jats:italic>p<\/jats:italic>\u2009=\u20090.001), and D0.1cc (<jats:italic>p<\/jats:italic>\u2009=\u20090.01) had a significant effect on TN toxicity. Cut\u2010off values leading to toxicity were determined as 66, 65.5, 65.25, 63.6, and 62.7\u2009Gy for Dmax, PTV\u2010TN Dmax, D0.1cc, D 0.5cc, and D1cc, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Radiation\u2010induced TN injury in head and neck cancer patients may further be investigated in clinically prospective trials by virtue of high toxicity rates with current RT doses in our retrospectively designed dosimetric study in parotid tumors.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.27524","type":"journal-article","created":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T05:03:59Z","timestamp":1695445439000},"page":"2907-2914","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Dosimetric investigation of radiation\u2010induced trigeminal nerve toxicity in parotid tumor patients"],"prefix":"10.1002","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4260-1018","authenticated-orcid":false,"given":"Sumerya","family":"Duru Birgi","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology Ankara University Faculty of Medicine  Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Serap","family":"Akyurek","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Ankara University Faculty of Medicine  Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erdem","family":"Birgi","sequence":"additional","affiliation":[{"name":"Department of Radiology University of Health Sciences, Diskapi Yildirim Beyazit Training and Research Hospital  Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yakup","family":"Arslan","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Ankara University Faculty of Medicine  Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Esra","family":"Gumustepe","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology University of Health Sciences, Gulhane Training and Research Hospital  Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Batuhan","family":"Bakirarar","sequence":"additional","affiliation":[{"name":"Department of Biostatistics Ankara University Faculty of Medicine  Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saban Cakir","family":"Gokce","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Ankara University Faculty of Medicine  Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,9,22]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjoms.2014.10.008"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.13952"},{"key":"e_1_2_9_4_1","unstructured":"NCCN.Clinical Practice Guidelines in Oncology (NCCN Guidelines\u00ae) Head and Neck Cancers. 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